Simultaneous determination of itraconazole and its CYP3A4-mediated metabolites including N-desalkyl itraconazole in human plasma using liquid chromatography-tandem mass spectrometry and its clinical application

BACKGROUND: Itraconazole (ITZ), a triazole antifungal agent, is metabolized to hydroxy-ITZ (OH-ITZ), keto-ITZ (KT-ITZ), and N-desalkyl ITZ (ND-ITZ) by cytochrome P450 3A4. The pharmacokinetics of ND-ITZ remain largely unknown due to the lack of an accurate and reliable determination method. This stu...

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Detalles Bibliográficos
Autores principales: Imoto, Yumi, Mino, Yasuaki, Naito, Takafumi, Ono, Takaaki, Kawakami, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199303/
https://www.ncbi.nlm.nih.gov/pubmed/32391164
http://dx.doi.org/10.1186/s40780-020-00167-7

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