Cargando…

IC100: a novel anti-ASC monoclonal antibody improves functional outcomes in an animal model of multiple sclerosis

BACKGROUND: The inflammasome adaptor apoptosis-associated speck-like protein containing a CARD (ASC) is involved in immune signaling by bridging the interactions between inflammasome sensors and caspase-1. Strong experimental evidence has shown that ASC(−/−) mice are protected from disease progressi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Desu, Haritha L., Plastini, Melanie, Illiano, Placido, Bramlett, Helen M., Dietrich, W. Dalton, de Rivero Vaccari, Juan Pablo, Brambilla, Roberta, Keane, Robert W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199312/ https://www.ncbi.nlm.nih.gov/pubmed/32366256 http://dx.doi.org/10.1186/s12974-020-01826-0

Ejemplares similares

Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis
por: Plastini, Melanie J., et al.
Publicado: (2020)

Mechanism of action of IC 100, a humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)
por: de Rivero Vaccari, Juan Pablo, et al.
Publicado: (2023)

Transcriptional abnormalities in induced pluripotent stem cell-derived oligodendrocytes of individuals with primary progressive multiple sclerosis
por: Plastini, Melanie J., et al.
Publicado: (2022)

The Inflammasome Adaptor Protein ASC in Mild Cognitive Impairment and Alzheimer’s Disease
por: Scott, Xavier O., et al.
Publicado: (2020)

TNFR2 Signaling Regulates the Immunomodulatory Function of Oligodendrocyte Precursor Cells
por: Desu, Haritha L., et al.
Publicado: (2021)

Inflammasome Proteins As Biomarkers of Multiple Sclerosis
por: Keane, Robert W., et al.
Publicado: (2018)

The Inflammasome Signaling Proteins ASC and IL-18 as Biomarkers of Psoriasis
por: Forouzandeh, Mahtab, et al.
Publicado: (2020)

Inflammasome activation in traumatic brain injury and Alzheimer’s disease
por: Johnson, Nathan H., et al.
Publicado: (2023)

ASC, IL-18 and Galectin-3 as Biomarkers of Non-Alcoholic Steatohepatitis: A Proof of Concept Study
por: Cyr, Brianna, et al.
Publicado: (2020)

Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer's disease
por: Vontell, Regina T., et al.
Publicado: (2022)

The Inflammasome in Times of COVID-19
por: de Rivero Vaccari, Juan Carlos, et al.
Publicado: (2020)

Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets
por: Govindarajan, Vaidya, et al.
Publicado: (2020)

The role of microglial inflammasome activation in pyroptotic cell death following penetrating traumatic brain injury
por: Lee, Stephanie W., et al.
Publicado: (2019)

Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats
por: Mawhinney, Lana J, et al.
Publicado: (2011)

Therapeutic hypothermia and targeted temperature management for traumatic brain injury: Experimental and clinical experience
por: Dietrich, W Dalton, et al.
Publicado: (2017)

RIG-1 receptor expression in the pathology of Alzheimer’s disease
por: de Rivero Vaccari, Juan Pablo, et al.
Publicado: (2014)

Agreement and repeatability of Icare ic100 tonometer
por: Jose, Judy, et al.
Publicado: (2020)

Human Lung Cell Pyroptosis Following Traumatic Brain Injury
por: Kerr, Nadine A., et al.
Publicado: (2019)

Is temperature an important variable in recovery after mild traumatic brain injury?
por: Atkins, Coleen M., et al.
Publicado: (2017)

Deep Tissue Injury in Development of Pressure Ulcers: A Decrease of Inflammasome Activation and Changes in Human Skin Morphology in Response to Aging and Mechanical Load
por: Stojadinovic, Olivera, et al.
Publicado: (2013)

Sexually dimorphic microglia and ischemic stroke
por: Kerr, Nadine, et al.
Publicado: (2019)

Inflammasome proteins as biomarkers of traumatic brain injury
por: Kerr, Nadine, et al.
Publicado: (2018)

The gray zone squamous lesions: ASC-US / ASC-H
por: Kattoor, Jayasree, et al.
Publicado: (2022)

Inflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke
por: Kerr, Nadine, et al.
Publicado: (2018)

Phase 1b dose-escalation, safety, and pharmacokinetic study of IC14, a monoclonal antibody against CD14, for the treatment of amyotrophic lateral sclerosis
por: Henderson, Robert D., et al.
Publicado: (2021)

Inflammasome signaling proteins as biomarkers of COVID-19
por: Hadad, Roey, et al.
Publicado: (2023)

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly
por: Schmidt, Florian I., et al.
Publicado: (2016)

Renal and Inflammatory Proteins as Biomarkers of Diabetic Kidney Disease and Lupus Nephritis
por: Johnson, Nathan H., et al.
Publicado: (2022)

EEGgui: a program used to detect electroencephalogram anomalies after traumatic brain injury
por: Sick, Justin, et al.
Publicado: (2013)

TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review
por: Komal, Asma, et al.
Publicado: (2021)

Mild Hyperthermia Aggravates Glucose Metabolic Consequences in Repetitive Concussion
por: Blaya, Meghan, et al.
Publicado: (2020)

The Role of Non-canonical and Canonical Inflammasomes in Inflammaging
por: Cyr, Brianna, et al.
Publicado: (2022)

Alimentation Sans Coupure (ASC)
por: Renaudot, C
Publicado: (1980)

Automated approach to detecting behavioral states using EEG-DABS
por: Loris, Zachary B., et al.
Publicado: (2017)

Dose-dependent modulation of microglia activation in rats after penetrating traumatic brain injury (pTBI) by transplanted human neural stem cells
por: Andreu, MaryLourdes, et al.
Publicado: (2023)

Inflammatory Biomarkers of Traumatic Brain Injury
por: Johnson, Nathan H., et al.
Publicado: (2022)

Enzymatically inactive procaspase-1 stabilizes the ASC-pyroptosome
por: Stein, R, et al.
Publicado: (2015)

The Crosstalk Between Adipose-Derived Stem or Stromal Cells (ASC) and Cancer Cells and ASC-Mediated Effects on Cancer Formation and Progression—ASCs: Safety Hazard or Harmless Source of Tropism?
por: Guillaume, Vincent G J, et al.
Publicado: (2022)

Applied Superconductivity Conference (ASC 1990)
por: Bardos, V A, et al.
Publicado: (1990)

Dynamics of in vivo ASC speck formation
por: Kuri, Paola, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6ujdh1h10pj1nkl0lf0dpa4pgc