Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis

ABSTRACT: The hydroxylase cytochrome P450 1A1 (CYP1A1) is regulated by the inflammation-limiting aryl hydrocarbon receptor (AhR), but CYP1A1 immune functions remain unclear. We observed CYP1A1 overexpression in peritoneal macrophages (PMs) isolated from mice following LPS or heat-killed Escherichia....

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Detalles Bibliográficos
Autores principales: Tian, Li-Xing, Tang, Xin, Zhu, Jun-Yu, Luo, Li, Ma, Xiao-Yuan, Cheng, Shao-Wen, Zhang, Wei, Tang, Wan-Qi, Ma, Wei, Yang, Xue, Lv, Chuan-Zhu, Liang, Hua-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199371/
https://www.ncbi.nlm.nih.gov/pubmed/32366266
http://dx.doi.org/10.1186/s12964-020-0523-3

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