Cargando…

Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and Inflammation

The multiple hit hypothesis for Parkinson’s disease (PD) suggests that an interaction between multiple (genetic and/or environmental) risk factors is needed to trigger the pathology. Leucine-Rich Repeat Kinase 2 (LRRK2) is an interesting protein to study in this context and is the focus of this revi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cabezudo, Diego, Baekelandt, Veerle, Lobbestael, Evy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199384/ https://www.ncbi.nlm.nih.gov/pubmed/32410948 http://dx.doi.org/10.3389/fnins.2020.00376

Ejemplares similares

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2
por: Vancraenenbroeck, Renée, et al.
Publicado: (2014)

Editorial: The Role of Lipids in the Pathogenesis of Parkinson's Disease
por: Baekelandt, Veerle, et al.
Publicado: (2020)

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
por: Taymans, Jean-Marc, et al.
Publicado: (2011)

RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A
por: Madero-Pérez, Jesús, et al.
Publicado: (2018)

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity
por: Lobbestael, Evy, et al.
Publicado: (2020)

Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization
por: De Wit, T., et al.
Publicado: (2018)

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues
por: Iannotta, Lucia, et al.
Publicado: (2020)

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2
por: Civiero, Laura, et al.
Publicado: (2017)

Mutant LRRK2 exacerbates immune response and neurodegeneration in a chronic model of experimental colitis
por: Cabezudo, Diego, et al.
Publicado: (2023)

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation
por: Lobbestael, E., et al.
Publicado: (2016)

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism
por: Taymans, Jean-Marc, et al.
Publicado: (2014)

Editorial: Protein Degradation Pathways in Parkinson's Disease and Neurodegeneration
por: Volta, Mattia, et al.
Publicado: (2020)

Modeling Parkinson’s disease in LRRK2 rodents
por: Domenicale, Chiara, et al.
Publicado: (2023)

LRRK2-Related Parkinson’s Disease Due to Altered Endolysosomal Biology With Variable Lewy Body Pathology: A Hypothesis
por: Rivero-Ríos, Pilar, et al.
Publicado: (2020)

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
por: Madero-Pérez, Jesús, et al.
Publicado: (2018)

The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology
por: Obergasteiger, Julia, et al.
Publicado: (2023)

Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases
por: Taymans, Jean-Marc, et al.
Publicado: (2014)

LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner
por: Kania, Elżbieta, et al.
Publicado: (2023)

RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase–mediated centrosomal cohesion and ciliogenesis deficits
por: Lara Ordónez, Antonio Jesús, et al.
Publicado: (2019)

Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions
por: Obergasteiger, Julia, et al.
Publicado: (2020)

The two-hit hypothesis for neuroinflammation: role of exogenous ATP in modulating inflammation in the brain
por: Fiebich, Bernd L., et al.
Publicado: (2014)

Progress in LRRK2-Associated Parkinson’s Disease Animal Models
por: Seegobin, Steven P., et al.
Publicado: (2020)

LRRK2 in Transcription and Translation Regulation: Relevance for Parkinson’s Disease
por: Dorval, Véronique, et al.
Publicado: (2012)

The function of Golgi apparatus in LRRK2-associated Parkinson’s disease
por: Wei, Yonghang, et al.
Publicado: (2023)

LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?
por: O’Hara, Darren M., et al.
Publicado: (2020)

LRRK2 and Protein Aggregation in Parkinson’s Disease: Insights From Animal Models
por: Dues, Dylan J., et al.
Publicado: (2020)

G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson’s Disease?
por: Ren, Chao, et al.
Publicado: (2019)

Modelling the functional genomics of Parkinson’s disease in Caenorhabditis elegans: LRRK2 and beyond
por: Chandler, Rachael J., et al.
Publicado: (2021)

ATP13A2 Regulates Cellular α-Synuclein Multimerization, Membrane Association, and Externalization
por: Si, Jianmin, et al.
Publicado: (2021)

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease
por: Rideout, Hardy J., et al.
Publicado: (2020)

Transgenic LRRK2(R1441G) rats–a model for Parkinson disease?
por: Shaikh, Komal T., et al.
Publicado: (2015)

A Comprehensive Analysis of Population Differences in LRRK2 Variant Distribution in Parkinson's Disease
por: Shu, Li, et al.
Publicado: (2019)

Clinical Heterogeneity Among LRRK2 Variants in Parkinson's Disease: A Meta-Analysis
por: Shu, Li, et al.
Publicado: (2018)

LRRK2 at the Interface Between Peripheral and Central Immune Function in Parkinson’s
por: Wallings, Rebecca L., et al.
Publicado: (2020)

Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson’s disease?
por: Nickels, Sarah Louise, et al.
Publicado: (2020)

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes
por: Sejwal, Kushal, et al.
Publicado: (2017)

Exploring Braak’s Hypothesis of Parkinson’s Disease
por: Rietdijk, Carmen D., et al.
Publicado: (2017)

Increased Levels of the Parkinson’s Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status
por: Di Leva, Francesca, et al.
Publicado: (2023)

Neuroprotection by the Immunomodulatory Drug Pomalidomide in the Drosophila LRRK2(WD40) Genetic Model of Parkinson’s Disease
por: Casu, Maria Antonietta, et al.
Publicado: (2020)

LRRK2 and Proteostasis in Parkinson’s Disease
por: Pérez-Carrión, María Dolores, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_89vdb891fkmq80l228r0p8r3q9