Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis

The relationship between mechanical force and alveolar bone remodeling is an important issue in orthodontics because tooth movement is dependent on the response of bone tissue to the mechanical force induced by the appliances used. Mechanical cyclical stretch plays an essential role in the cell oste...

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Detalles Bibliográficos
Autores principales: Guo, Qingyuan, Liu, Ying, Sun, Renhao, Yang, Fang, Qiao, Pengyan, Zhang, Rong, Song, Ling, E, Lingling, Liu, Hongchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199451/
https://www.ncbi.nlm.nih.gov/pubmed/32309849
http://dx.doi.org/10.1042/BSR20193876
Descripción
Sumario:The relationship between mechanical force and alveolar bone remodeling is an important issue in orthodontics because tooth movement is dependent on the response of bone tissue to the mechanical force induced by the appliances used. Mechanical cyclical stretch plays an essential role in the cell osteogenic differentiation involved in bone remodeling. However, the underlying mechanisms are unclear, particularly the molecular pathways regulated by mechanical stimulation. In the present study, we reported a dynamic change of p21 level in response to mechanical cyclical stretch, and shRNA-p21 in bone marrow mesenchymal stem cells (BMSCs) induced osteogenic differentiation. The mechanism was mediated through TWIST/E2A/p21 axis. These results supported the mechanical stimulation-induced osteogenic differentiation is negatively regulated by p21.

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