Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis

The relationship between mechanical force and alveolar bone remodeling is an important issue in orthodontics because tooth movement is dependent on the response of bone tissue to the mechanical force induced by the appliances used. Mechanical cyclical stretch plays an essential role in the cell oste...

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Detalles Bibliográficos
Autores principales: Guo, Qingyuan, Liu, Ying, Sun, Renhao, Yang, Fang, Qiao, Pengyan, Zhang, Rong, Song, Ling, E, Lingling, Liu, Hongchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199451/
https://www.ncbi.nlm.nih.gov/pubmed/32309849
http://dx.doi.org/10.1042/BSR20193876
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author Guo, Qingyuan
Liu, Ying
Sun, Renhao
Yang, Fang
Qiao, Pengyan
Zhang, Rong
Song, Ling
E, Lingling
Liu, Hongchen
author_facet Guo, Qingyuan
Liu, Ying
Sun, Renhao
Yang, Fang
Qiao, Pengyan
Zhang, Rong
Song, Ling
E, Lingling
Liu, Hongchen
author_sort Guo, Qingyuan
collection PubMed
description The relationship between mechanical force and alveolar bone remodeling is an important issue in orthodontics because tooth movement is dependent on the response of bone tissue to the mechanical force induced by the appliances used. Mechanical cyclical stretch plays an essential role in the cell osteogenic differentiation involved in bone remodeling. However, the underlying mechanisms are unclear, particularly the molecular pathways regulated by mechanical stimulation. In the present study, we reported a dynamic change of p21 level in response to mechanical cyclical stretch, and shRNA-p21 in bone marrow mesenchymal stem cells (BMSCs) induced osteogenic differentiation. The mechanism was mediated through TWIST/E2A/p21 axis. These results supported the mechanical stimulation-induced osteogenic differentiation is negatively regulated by p21.
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spelling pubmed-71994512020-05-13 Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis Guo, Qingyuan Liu, Ying Sun, Renhao Yang, Fang Qiao, Pengyan Zhang, Rong Song, Ling E, Lingling Liu, Hongchen Biosci Rep Developmental Biology The relationship between mechanical force and alveolar bone remodeling is an important issue in orthodontics because tooth movement is dependent on the response of bone tissue to the mechanical force induced by the appliances used. Mechanical cyclical stretch plays an essential role in the cell osteogenic differentiation involved in bone remodeling. However, the underlying mechanisms are unclear, particularly the molecular pathways regulated by mechanical stimulation. In the present study, we reported a dynamic change of p21 level in response to mechanical cyclical stretch, and shRNA-p21 in bone marrow mesenchymal stem cells (BMSCs) induced osteogenic differentiation. The mechanism was mediated through TWIST/E2A/p21 axis. These results supported the mechanical stimulation-induced osteogenic differentiation is negatively regulated by p21. Portland Press Ltd. 2020-05-04 /pmc/articles/PMC7199451/ /pubmed/32309849 http://dx.doi.org/10.1042/BSR20193876 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Developmental Biology
Guo, Qingyuan
Liu, Ying
Sun, Renhao
Yang, Fang
Qiao, Pengyan
Zhang, Rong
Song, Ling
E, Lingling
Liu, Hongchen
Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis
title Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis
title_full Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis
title_fullStr Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis
title_full_unstemmed Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis
title_short Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis
title_sort mechanical stimulation induced osteogenic differentiation of bmscs through twist/e2a/p21 axis
topic Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199451/
https://www.ncbi.nlm.nih.gov/pubmed/32309849
http://dx.doi.org/10.1042/BSR20193876
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