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From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches

A healthy body activates the immune response to target invading pathogens (i.e. viruses, bacteria, fungi, and parasites) and avoid further systemic infection. The activation of immunological mechanisms includes several components of the immune system, such as innate and acquired immunity. Once any c...

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Detalles Bibliográficos
Autores principales: Hu, Qinghe, Hao, Cuiping, Tang, Sujuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199454/
https://www.ncbi.nlm.nih.gov/pubmed/32319516
http://dx.doi.org/10.1042/BSR20200830
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author Hu, Qinghe
Hao, Cuiping
Tang, Sujuan
author_facet Hu, Qinghe
Hao, Cuiping
Tang, Sujuan
author_sort Hu, Qinghe
collection PubMed
description A healthy body activates the immune response to target invading pathogens (i.e. viruses, bacteria, fungi, and parasites) and avoid further systemic infection. The activation of immunological mechanisms includes several components of the immune system, such as innate and acquired immunity. Once any component of the immune response to infections is aberrantly altered or dysregulated, resulting in a failure to clear infection, sepsis will develop through a pro-inflammatory immunological mechanism. Furthermore, the severe inflammatory responses induced by sepsis also increase vascular permeability, leading to acute pulmonary edema and resulting in acute respiratory distress syndrome (ARDS). Apparently, potential for improvement exists in the management of the transition from sepsis to ARDS; thus, this article presents an exhaustive review that highlights the previously unrecognized relationship between sepsis and ARDS and suggests a direction for future therapeutic developments, including plasma and genetic pre-diagnostic strategies and interference with proinflammatory signaling.
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spelling pubmed-71994542020-05-13 From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches Hu, Qinghe Hao, Cuiping Tang, Sujuan Biosci Rep Molecular Bases of Health & Disease A healthy body activates the immune response to target invading pathogens (i.e. viruses, bacteria, fungi, and parasites) and avoid further systemic infection. The activation of immunological mechanisms includes several components of the immune system, such as innate and acquired immunity. Once any component of the immune response to infections is aberrantly altered or dysregulated, resulting in a failure to clear infection, sepsis will develop through a pro-inflammatory immunological mechanism. Furthermore, the severe inflammatory responses induced by sepsis also increase vascular permeability, leading to acute pulmonary edema and resulting in acute respiratory distress syndrome (ARDS). Apparently, potential for improvement exists in the management of the transition from sepsis to ARDS; thus, this article presents an exhaustive review that highlights the previously unrecognized relationship between sepsis and ARDS and suggests a direction for future therapeutic developments, including plasma and genetic pre-diagnostic strategies and interference with proinflammatory signaling. Portland Press Ltd. 2020-05-04 /pmc/articles/PMC7199454/ /pubmed/32319516 http://dx.doi.org/10.1042/BSR20200830 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Molecular Bases of Health & Disease
Hu, Qinghe
Hao, Cuiping
Tang, Sujuan
From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches
title From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches
title_full From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches
title_fullStr From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches
title_full_unstemmed From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches
title_short From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches
title_sort from sepsis to acute respiratory distress syndrome (ards): emerging preventive strategies based on molecular and genetic researches
topic Molecular Bases of Health & Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199454/
https://www.ncbi.nlm.nih.gov/pubmed/32319516
http://dx.doi.org/10.1042/BSR20200830
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