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Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers
Tumors are surrounded by complex environmental components, including blood and lymph vessels, fibroblasts, endothelial cells, immune cells, cytokines, extracellular vesicles, and extracellular matrix. All the stromal components together with the tumor cells form the tumor microenvironment (TME). In...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199555/ https://www.ncbi.nlm.nih.gov/pubmed/32377504 http://dx.doi.org/10.1155/2020/6283796 |
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author | Wei, Rui Liu, Si Zhang, Shutian Min, Li Zhu, Shengtao |
author_facet | Wei, Rui Liu, Si Zhang, Shutian Min, Li Zhu, Shengtao |
author_sort | Wei, Rui |
collection | PubMed |
description | Tumors are surrounded by complex environmental components, including blood and lymph vessels, fibroblasts, endothelial cells, immune cells, cytokines, extracellular vesicles, and extracellular matrix. All the stromal components together with the tumor cells form the tumor microenvironment (TME). In addition, extracellular physical and chemical factors, including extracellular pH, hypoxia, elevated interstitial fluid pressure, and fibrosis, are closely associated with tumor progression, metastasis, immunosuppression, and drug resistance. Cellular and extracellular components in TME contribute to nearly all procedures of carcinogenesis. By summarizing the recent work in this field, we make a comprehensive review on the role of cellular and extracellular components in the process of carcinogenesis and their potential application in early diagnosis of cancer. We hope that a systematic review of the diverse aspects of TME will help both research scientists and clinicians in this field. |
format | Online Article Text |
id | pubmed-7199555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-71995552020-05-06 Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers Wei, Rui Liu, Si Zhang, Shutian Min, Li Zhu, Shengtao Anal Cell Pathol (Amst) Review Article Tumors are surrounded by complex environmental components, including blood and lymph vessels, fibroblasts, endothelial cells, immune cells, cytokines, extracellular vesicles, and extracellular matrix. All the stromal components together with the tumor cells form the tumor microenvironment (TME). In addition, extracellular physical and chemical factors, including extracellular pH, hypoxia, elevated interstitial fluid pressure, and fibrosis, are closely associated with tumor progression, metastasis, immunosuppression, and drug resistance. Cellular and extracellular components in TME contribute to nearly all procedures of carcinogenesis. By summarizing the recent work in this field, we make a comprehensive review on the role of cellular and extracellular components in the process of carcinogenesis and their potential application in early diagnosis of cancer. We hope that a systematic review of the diverse aspects of TME will help both research scientists and clinicians in this field. Hindawi 2020-01-08 /pmc/articles/PMC7199555/ /pubmed/32377504 http://dx.doi.org/10.1155/2020/6283796 Text en Copyright © 2020 Rui Wei et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wei, Rui Liu, Si Zhang, Shutian Min, Li Zhu, Shengtao Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers |
title | Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers |
title_full | Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers |
title_fullStr | Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers |
title_full_unstemmed | Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers |
title_short | Cellular and Extracellular Components in Tumor Microenvironment and Their Application in Early Diagnosis of Cancers |
title_sort | cellular and extracellular components in tumor microenvironment and their application in early diagnosis of cancers |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199555/ https://www.ncbi.nlm.nih.gov/pubmed/32377504 http://dx.doi.org/10.1155/2020/6283796 |
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