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“Olfactory Three-Needle” Enhances Spatial Learning and Memory Ability in SAMP8 Mice

As one of the most important therapies in complementary and alternative medicine, acupuncture has been used in the treatment of Alzheimer's disease (AD). Acupuncture of “olfactory three-needle” manipulation can improve the cognitive ability of AD patients. However, the mechanism of “olfactory t...

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Autores principales: Wang, Yuan, Wang, Qiang, Ren, Bo, Guo, Ting, Qiang, Jing, Cao, Hui, Gao, Yujie, Liu, Zhibin, Gao, Xinyan, Zhu, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199563/
https://www.ncbi.nlm.nih.gov/pubmed/32377265
http://dx.doi.org/10.1155/2020/2893289
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author Wang, Yuan
Wang, Qiang
Ren, Bo
Guo, Ting
Qiang, Jing
Cao, Hui
Gao, Yujie
Liu, Zhibin
Gao, Xinyan
Zhu, Bing
author_facet Wang, Yuan
Wang, Qiang
Ren, Bo
Guo, Ting
Qiang, Jing
Cao, Hui
Gao, Yujie
Liu, Zhibin
Gao, Xinyan
Zhu, Bing
author_sort Wang, Yuan
collection PubMed
description As one of the most important therapies in complementary and alternative medicine, acupuncture has been used in the treatment of Alzheimer's disease (AD). Acupuncture of “olfactory three-needle” manipulation can improve the cognitive ability of AD patients. However, the mechanism of “olfactory three-needle” in AD remains largely unknown. Here, we identified that the “olfactory three-needle” therapy and eugenol olfactory stimulation both reduced the deposition of β-amyloid (Aβ) protein and increased the expression of synaptophysin (SYP), but only the “olfactory three-needle” enhanced the spatial learning and memory ability of SAMP8. Remarkably, the “olfactory three-needle” inhibited the phosphorylation of p38MAPK and the excessive activation of microglia (MG) in the hippocampus. Our study demonstrates that the “olfactory three-needle” enhances spatial learning and memory ability by inhibiting the phosphorylation of p38MAPK and the excessive activation of MG to reduce the neuroinflammatory response and neurotoxicity of Aβ and promote synaptic regeneration, but it was not completely consistent with the stimulation of the olfactory system.
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spelling pubmed-71995632020-05-06 “Olfactory Three-Needle” Enhances Spatial Learning and Memory Ability in SAMP8 Mice Wang, Yuan Wang, Qiang Ren, Bo Guo, Ting Qiang, Jing Cao, Hui Gao, Yujie Liu, Zhibin Gao, Xinyan Zhu, Bing Behav Neurol Research Article As one of the most important therapies in complementary and alternative medicine, acupuncture has been used in the treatment of Alzheimer's disease (AD). Acupuncture of “olfactory three-needle” manipulation can improve the cognitive ability of AD patients. However, the mechanism of “olfactory three-needle” in AD remains largely unknown. Here, we identified that the “olfactory three-needle” therapy and eugenol olfactory stimulation both reduced the deposition of β-amyloid (Aβ) protein and increased the expression of synaptophysin (SYP), but only the “olfactory three-needle” enhanced the spatial learning and memory ability of SAMP8. Remarkably, the “olfactory three-needle” inhibited the phosphorylation of p38MAPK and the excessive activation of microglia (MG) in the hippocampus. Our study demonstrates that the “olfactory three-needle” enhances spatial learning and memory ability by inhibiting the phosphorylation of p38MAPK and the excessive activation of MG to reduce the neuroinflammatory response and neurotoxicity of Aβ and promote synaptic regeneration, but it was not completely consistent with the stimulation of the olfactory system. Hindawi 2020-01-02 /pmc/articles/PMC7199563/ /pubmed/32377265 http://dx.doi.org/10.1155/2020/2893289 Text en Copyright © 2020 Yuan Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Yuan
Wang, Qiang
Ren, Bo
Guo, Ting
Qiang, Jing
Cao, Hui
Gao, Yujie
Liu, Zhibin
Gao, Xinyan
Zhu, Bing
“Olfactory Three-Needle” Enhances Spatial Learning and Memory Ability in SAMP8 Mice
title “Olfactory Three-Needle” Enhances Spatial Learning and Memory Ability in SAMP8 Mice
title_full “Olfactory Three-Needle” Enhances Spatial Learning and Memory Ability in SAMP8 Mice
title_fullStr “Olfactory Three-Needle” Enhances Spatial Learning and Memory Ability in SAMP8 Mice
title_full_unstemmed “Olfactory Three-Needle” Enhances Spatial Learning and Memory Ability in SAMP8 Mice
title_short “Olfactory Three-Needle” Enhances Spatial Learning and Memory Ability in SAMP8 Mice
title_sort “olfactory three-needle” enhances spatial learning and memory ability in samp8 mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199563/
https://www.ncbi.nlm.nih.gov/pubmed/32377265
http://dx.doi.org/10.1155/2020/2893289
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