PPARs and the Development of Type 1 Diabetes

Peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors with a key role in glucose and lipid metabolism. PPARs are expressed in many cell types including pancreatic beta cells and immune cells, where they regulate insulin secretion and T cell differentiation, respec...

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Detalles Bibliográficos
Autores principales: Holm, Laurits J., Mønsted, Mia Øgaard, Haupt-Jorgensen, Martin, Buschard, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199578/
https://www.ncbi.nlm.nih.gov/pubmed/32395123
http://dx.doi.org/10.1155/2020/6198628
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author Holm, Laurits J.
Mønsted, Mia Øgaard
Haupt-Jorgensen, Martin
Buschard, Karsten
author_facet Holm, Laurits J.
Mønsted, Mia Øgaard
Haupt-Jorgensen, Martin
Buschard, Karsten
author_sort Holm, Laurits J.
collection PubMed
description Peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors with a key role in glucose and lipid metabolism. PPARs are expressed in many cell types including pancreatic beta cells and immune cells, where they regulate insulin secretion and T cell differentiation, respectively. Moreover, various PPAR agonists prevent diabetes in the non-obese diabetic (NOD) mouse model of type 1 diabetes. PPARs are thus of interest in type 1 diabetes (T1D) as they represent a novel approach targeting both the pancreas and the immune system. In this review, we examine the role of PPARs in immune responses and beta cell biology and their potential as targets for treatment of T1D.
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spelling pubmed-71995782020-05-11 PPARs and the Development of Type 1 Diabetes Holm, Laurits J. Mønsted, Mia Øgaard Haupt-Jorgensen, Martin Buschard, Karsten PPAR Res Review Article Peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors with a key role in glucose and lipid metabolism. PPARs are expressed in many cell types including pancreatic beta cells and immune cells, where they regulate insulin secretion and T cell differentiation, respectively. Moreover, various PPAR agonists prevent diabetes in the non-obese diabetic (NOD) mouse model of type 1 diabetes. PPARs are thus of interest in type 1 diabetes (T1D) as they represent a novel approach targeting both the pancreas and the immune system. In this review, we examine the role of PPARs in immune responses and beta cell biology and their potential as targets for treatment of T1D. Hindawi 2020-01-09 /pmc/articles/PMC7199578/ /pubmed/32395123 http://dx.doi.org/10.1155/2020/6198628 Text en Copyright © 2020 Laurits J. Holm et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Holm, Laurits J.
Mønsted, Mia Øgaard
Haupt-Jorgensen, Martin
Buschard, Karsten
PPARs and the Development of Type 1 Diabetes
title PPARs and the Development of Type 1 Diabetes
title_full PPARs and the Development of Type 1 Diabetes
title_fullStr PPARs and the Development of Type 1 Diabetes
title_full_unstemmed PPARs and the Development of Type 1 Diabetes
title_short PPARs and the Development of Type 1 Diabetes
title_sort ppars and the development of type 1 diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199578/
https://www.ncbi.nlm.nih.gov/pubmed/32395123
http://dx.doi.org/10.1155/2020/6198628
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AT buschardkarsten pparsandthedevelopmentoftype1diabetes

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