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More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy?
The bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a mitochondrial one-carbon folate metabolic enzyme whose role in cancer was not known until recently. MTHFD2 is highly expressed in embryos and a wide range of tumors but has low or absent expression in most adult di...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199629/ https://www.ncbi.nlm.nih.gov/pubmed/32411609 http://dx.doi.org/10.3389/fonc.2020.00658 |