A cautionary tale of false-negative nasopharyngeal COVID-19 testing

There remains diagnostic uncertainty regarding the sensitivity of reverse transcription polymerase chain reaction in detection of SARS-CoV-2 from nasopharyngeal specimens. We present a case where two nasopharyngeal specimens were negative, followed by a positive sputum sample. Serial testing for COV...

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Detalles Bibliográficos
Autores principales: Bullis, Sean S.M., Crothers, Jessica W., Wayne, Shawn, Hale, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199681/
https://www.ncbi.nlm.nih.gov/pubmed/32377507
http://dx.doi.org/10.1016/j.idcr.2020.e00791
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author Bullis, Sean S.M.
Crothers, Jessica W.
Wayne, Shawn
Hale, Andrew J.
author_facet Bullis, Sean S.M.
Crothers, Jessica W.
Wayne, Shawn
Hale, Andrew J.
author_sort Bullis, Sean S.M.
collection PubMed
description There remains diagnostic uncertainty regarding the sensitivity of reverse transcription polymerase chain reaction in detection of SARS-CoV-2 from nasopharyngeal specimens. We present a case where two nasopharyngeal specimens were negative, followed by a positive sputum sample. Serial testing for COVID-19 is indicated in patients with high pretest probability of disease.
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spelling pubmed-71996812020-05-06 A cautionary tale of false-negative nasopharyngeal COVID-19 testing Bullis, Sean S.M. Crothers, Jessica W. Wayne, Shawn Hale, Andrew J. IDCases Article There remains diagnostic uncertainty regarding the sensitivity of reverse transcription polymerase chain reaction in detection of SARS-CoV-2 from nasopharyngeal specimens. We present a case where two nasopharyngeal specimens were negative, followed by a positive sputum sample. Serial testing for COVID-19 is indicated in patients with high pretest probability of disease. Elsevier 2020-05-05 /pmc/articles/PMC7199681/ /pubmed/32377507 http://dx.doi.org/10.1016/j.idcr.2020.e00791 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Bullis, Sean S.M.
Crothers, Jessica W.
Wayne, Shawn
Hale, Andrew J.
A cautionary tale of false-negative nasopharyngeal COVID-19 testing
title A cautionary tale of false-negative nasopharyngeal COVID-19 testing
title_full A cautionary tale of false-negative nasopharyngeal COVID-19 testing
title_fullStr A cautionary tale of false-negative nasopharyngeal COVID-19 testing
title_full_unstemmed A cautionary tale of false-negative nasopharyngeal COVID-19 testing
title_short A cautionary tale of false-negative nasopharyngeal COVID-19 testing
title_sort cautionary tale of false-negative nasopharyngeal covid-19 testing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199681/
https://www.ncbi.nlm.nih.gov/pubmed/32377507
http://dx.doi.org/10.1016/j.idcr.2020.e00791
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