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Free DNA, a reason for severe COVID-19 infection?

The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. Howev...

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Detalles Bibliográficos
Autor principal: Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199685/
https://www.ncbi.nlm.nih.gov/pubmed/32416412
http://dx.doi.org/10.1016/j.mehy.2020.109812
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author Liu, Bin
author_facet Liu, Bin
author_sort Liu, Bin
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description The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. However, the etiology of severe COVID-19 has been largely unknown. Similar as SARS-CoV and MERS-CoV, SARS-CoV-2 is also thought derived from bat coronaviruses. However, it is not pathogenic for bat at all, because free DNA in cytoplasm or blood cannot bring up violent immune response in bat; but it can produce severe inflammations in human. I hypothesized that the damage induced by free DNA is a reason for severe COVID-19, which can explain many symptoms of this disease, such as cytokine storm, acute respiratory distress syndrome (ARDS) and muscus plug, acute injuries of heart, liver and kidney, and some special symptoms of COVID-19. My hypothesis will be helpful for better understand the etiology of severe COVID-19.
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spelling pubmed-71996852020-05-06 Free DNA, a reason for severe COVID-19 infection? Liu, Bin Med Hypotheses Article The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. However, the etiology of severe COVID-19 has been largely unknown. Similar as SARS-CoV and MERS-CoV, SARS-CoV-2 is also thought derived from bat coronaviruses. However, it is not pathogenic for bat at all, because free DNA in cytoplasm or blood cannot bring up violent immune response in bat; but it can produce severe inflammations in human. I hypothesized that the damage induced by free DNA is a reason for severe COVID-19, which can explain many symptoms of this disease, such as cytokine storm, acute respiratory distress syndrome (ARDS) and muscus plug, acute injuries of heart, liver and kidney, and some special symptoms of COVID-19. My hypothesis will be helpful for better understand the etiology of severe COVID-19. Elsevier Ltd. 2020-09 2020-05-05 /pmc/articles/PMC7199685/ /pubmed/32416412 http://dx.doi.org/10.1016/j.mehy.2020.109812 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Liu, Bin
Free DNA, a reason for severe COVID-19 infection?
title Free DNA, a reason for severe COVID-19 infection?
title_full Free DNA, a reason for severe COVID-19 infection?
title_fullStr Free DNA, a reason for severe COVID-19 infection?
title_full_unstemmed Free DNA, a reason for severe COVID-19 infection?
title_short Free DNA, a reason for severe COVID-19 infection?
title_sort free dna, a reason for severe covid-19 infection?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199685/
https://www.ncbi.nlm.nih.gov/pubmed/32416412
http://dx.doi.org/10.1016/j.mehy.2020.109812
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