A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance

Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of...

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Detalles Bibliográficos
Autores principales: Milanese, Chiara, Mastroberardino, Pier G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199736/
https://www.ncbi.nlm.nih.gov/pubmed/32391425
http://dx.doi.org/10.1080/23723556.2020.1733383
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author Milanese, Chiara
Mastroberardino, Pier G.
author_facet Milanese, Chiara
Mastroberardino, Pier G.
author_sort Milanese, Chiara
collection PubMed
description Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development.
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spelling pubmed-71997362020-09-28 A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance Milanese, Chiara Mastroberardino, Pier G. Mol Cell Oncol Author's Views Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development. Taylor & Francis 2020-03-22 /pmc/articles/PMC7199736/ /pubmed/32391425 http://dx.doi.org/10.1080/23723556.2020.1733383 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Milanese, Chiara
Mastroberardino, Pier G.
A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
title A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
title_full A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
title_fullStr A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
title_full_unstemmed A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
title_short A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
title_sort perspective on dna damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199736/
https://www.ncbi.nlm.nih.gov/pubmed/32391425
http://dx.doi.org/10.1080/23723556.2020.1733383
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