PBRM1 suppresses tumor growth as a novel p53 acetylation reader

The reader(s) for acetylated tumor antigen p53 remains elusive. Here, PBRM1 (polybromo-1) is identified as a reader for acetylated lysine382 on p53 through its bromodomain 4 (BD4). PBRM1 BD4 mutants fail to support p53 transcriptional activity and suppress tumor growth. Thus PBRM1 suppresses tumor g...

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Detalles Bibliográficos
Autores principales: Cai, Weijia, Su, Liya, Yang, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199739/
https://www.ncbi.nlm.nih.gov/pubmed/32391422
http://dx.doi.org/10.1080/23723556.2020.1729680
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author Cai, Weijia
Su, Liya
Yang, Haifeng
author_facet Cai, Weijia
Su, Liya
Yang, Haifeng
author_sort Cai, Weijia
collection PubMed
description The reader(s) for acetylated tumor antigen p53 remains elusive. Here, PBRM1 (polybromo-1) is identified as a reader for acetylated lysine382 on p53 through its bromodomain 4 (BD4). PBRM1 BD4 mutants fail to support p53 transcriptional activity and suppress tumor growth. Thus PBRM1 suppresses tumor growth through p53 in kidney cancer.
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spelling pubmed-71997392020-09-28 PBRM1 suppresses tumor growth as a novel p53 acetylation reader Cai, Weijia Su, Liya Yang, Haifeng Mol Cell Oncol Author's Views The reader(s) for acetylated tumor antigen p53 remains elusive. Here, PBRM1 (polybromo-1) is identified as a reader for acetylated lysine382 on p53 through its bromodomain 4 (BD4). PBRM1 BD4 mutants fail to support p53 transcriptional activity and suppress tumor growth. Thus PBRM1 suppresses tumor growth through p53 in kidney cancer. Taylor & Francis 2020-03-11 /pmc/articles/PMC7199739/ /pubmed/32391422 http://dx.doi.org/10.1080/23723556.2020.1729680 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Cai, Weijia
Su, Liya
Yang, Haifeng
PBRM1 suppresses tumor growth as a novel p53 acetylation reader
title PBRM1 suppresses tumor growth as a novel p53 acetylation reader
title_full PBRM1 suppresses tumor growth as a novel p53 acetylation reader
title_fullStr PBRM1 suppresses tumor growth as a novel p53 acetylation reader
title_full_unstemmed PBRM1 suppresses tumor growth as a novel p53 acetylation reader
title_short PBRM1 suppresses tumor growth as a novel p53 acetylation reader
title_sort pbrm1 suppresses tumor growth as a novel p53 acetylation reader
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199739/
https://www.ncbi.nlm.nih.gov/pubmed/32391422
http://dx.doi.org/10.1080/23723556.2020.1729680
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