What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation

Myosin II and its regulator Rho-associated coiled-coil containing protein kinase (ROCK) are essential for cell invasion and metastatic dissemination. Our recent findings show that this molecular machinery is also involved in drug resistance in melanoma by playing a dual role: protection of tumor cel...

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Autores principales: Orgaz, Jose L, Sanz-Moreno, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199747/
https://www.ncbi.nlm.nih.gov/pubmed/32391428
http://dx.doi.org/10.1080/23723556.2020.1735911
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author Orgaz, Jose L
Sanz-Moreno, Victoria
author_facet Orgaz, Jose L
Sanz-Moreno, Victoria
author_sort Orgaz, Jose L
collection PubMed
description Myosin II and its regulator Rho-associated coiled-coil containing protein kinase (ROCK) are essential for cell invasion and metastatic dissemination. Our recent findings show that this molecular machinery is also involved in drug resistance in melanoma by playing a dual role: protection of tumor cells from reactive oxygen species (ROS) and DNA damage (intrinsic), and co-option of myeloid and lymphoid populations to establish immunosuppression (extrinsic).
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spelling pubmed-71997472020-09-28 What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation Orgaz, Jose L Sanz-Moreno, Victoria Mol Cell Oncol Author's Views Myosin II and its regulator Rho-associated coiled-coil containing protein kinase (ROCK) are essential for cell invasion and metastatic dissemination. Our recent findings show that this molecular machinery is also involved in drug resistance in melanoma by playing a dual role: protection of tumor cells from reactive oxygen species (ROS) and DNA damage (intrinsic), and co-option of myeloid and lymphoid populations to establish immunosuppression (extrinsic). Taylor & Francis 2020-03-26 /pmc/articles/PMC7199747/ /pubmed/32391428 http://dx.doi.org/10.1080/23723556.2020.1735911 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author's Views
Orgaz, Jose L
Sanz-Moreno, Victoria
What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation
title What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation
title_full What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation
title_fullStr What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation
title_full_unstemmed What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation
title_short What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation
title_sort what does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and myosin ii reactivation
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199747/
https://www.ncbi.nlm.nih.gov/pubmed/32391428
http://dx.doi.org/10.1080/23723556.2020.1735911
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