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Ferroptosis resistance mediated by exosomal release of iron
Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases. We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome traffi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199748/ https://www.ncbi.nlm.nih.gov/pubmed/32391424 http://dx.doi.org/10.1080/23723556.2020.1730144 |
| _version_ | 1783529207278600192 |
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| author | Brown, Caitlin W. Mercurio, Arthur M. |
| author_facet | Brown, Caitlin W. Mercurio, Arthur M. |
| author_sort | Brown, Caitlin W. |
| collection | PubMed |
| description | Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases. We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis. |
| format | Online Article Text |
| id | pubmed-7199748 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71997482020-09-28 Ferroptosis resistance mediated by exosomal release of iron Brown, Caitlin W. Mercurio, Arthur M. Mol Cell Oncol Author's Views Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases. We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis. Taylor & Francis 2020-03-21 /pmc/articles/PMC7199748/ /pubmed/32391424 http://dx.doi.org/10.1080/23723556.2020.1730144 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
| spellingShingle | Author's Views Brown, Caitlin W. Mercurio, Arthur M. Ferroptosis resistance mediated by exosomal release of iron |
| title | Ferroptosis resistance mediated by exosomal release of iron |
| title_full | Ferroptosis resistance mediated by exosomal release of iron |
| title_fullStr | Ferroptosis resistance mediated by exosomal release of iron |
| title_full_unstemmed | Ferroptosis resistance mediated by exosomal release of iron |
| title_short | Ferroptosis resistance mediated by exosomal release of iron |
| title_sort | ferroptosis resistance mediated by exosomal release of iron |
| topic | Author's Views |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199748/ https://www.ncbi.nlm.nih.gov/pubmed/32391424 http://dx.doi.org/10.1080/23723556.2020.1730144 |
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