A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity

Basal-like breast cancers have the highest rates of locoregional recurrence after radiation. By correlating gene expression with early locoregional recurrence, we nominate TTK protein kinase as a mediator of radioresistance. TTK inhibition radiosensitizes in vitro and in vivo through a novel mechani...

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Detalles Bibliográficos
Autores principales: Chandler, Benjamin C., Speers, Corey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199749/
https://www.ncbi.nlm.nih.gov/pubmed/32391431
http://dx.doi.org/10.1080/23723556.2020.1737771
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author Chandler, Benjamin C.
Speers, Corey
author_facet Chandler, Benjamin C.
Speers, Corey
author_sort Chandler, Benjamin C.
collection PubMed
description Basal-like breast cancers have the highest rates of locoregional recurrence after radiation. By correlating gene expression with early locoregional recurrence, we nominate TTK protein kinase as a mediator of radioresistance. TTK inhibition radiosensitizes in vitro and in vivo through a novel mechanism of impaired homologous recombination and represents a promising translational strategy.
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spelling pubmed-71997492020-09-28 A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity Chandler, Benjamin C. Speers, Corey Mol Cell Oncol Author's Views Basal-like breast cancers have the highest rates of locoregional recurrence after radiation. By correlating gene expression with early locoregional recurrence, we nominate TTK protein kinase as a mediator of radioresistance. TTK inhibition radiosensitizes in vitro and in vivo through a novel mechanism of impaired homologous recombination and represents a promising translational strategy. Taylor & Francis 2020-03-19 /pmc/articles/PMC7199749/ /pubmed/32391431 http://dx.doi.org/10.1080/23723556.2020.1737771 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Chandler, Benjamin C.
Speers, Corey
A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity
title A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity
title_full A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity
title_fullStr A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity
title_full_unstemmed A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity
title_short A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity
title_sort novel role for ttk in homologous recombination: implications for breast cancer radiosensitivity
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199749/
https://www.ncbi.nlm.nih.gov/pubmed/32391431
http://dx.doi.org/10.1080/23723556.2020.1737771
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