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Protective role of p53 in doxorubicin-induced cardiomyopathy as a mitochondrial disease
Doxorubicin is widely used against cancer but carries the risk of a progressive cardiomyopathy associated with mitochondrial loss. Using genetic models, our recent study demonstrates that mitochondrial genomic DNA regulation by tumor protein p53 (TP53, best known as p53) prevents the cardiotoxicity...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199752/ https://www.ncbi.nlm.nih.gov/pubmed/32391420 http://dx.doi.org/10.1080/23723556.2020.1724598 |