Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins

Repetitive sequences can form a variety of alternative DNA structures (non-B DNA) that can modulate transcription, replication, and repair. However, non-B DNA-forming sequences can also stimulate mutagenesis, and are enriched at mutation hotspots in human cancer genomes. Interestingly, different typ...

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Detalles Bibliográficos
Autores principales: McKinney, Jennifer A., Wang, Guliang, Vasquez, Karen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199757/
https://www.ncbi.nlm.nih.gov/pubmed/32391433
http://dx.doi.org/10.1080/23723556.2020.1743807
Descripción
Sumario:Repetitive sequences can form a variety of alternative DNA structures (non-B DNA) that can modulate transcription, replication, and repair. However, non-B DNA-forming sequences can also stimulate mutagenesis, and are enriched at mutation hotspots in human cancer genomes. Interestingly, different types of non-B DNA stimulate mutagenesis via distinct repair processing mechanisms.

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