Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins

Repetitive sequences can form a variety of alternative DNA structures (non-B DNA) that can modulate transcription, replication, and repair. However, non-B DNA-forming sequences can also stimulate mutagenesis, and are enriched at mutation hotspots in human cancer genomes. Interestingly, different typ...

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Autores principales: McKinney, Jennifer A., Wang, Guliang, Vasquez, Karen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199757/
https://www.ncbi.nlm.nih.gov/pubmed/32391433
http://dx.doi.org/10.1080/23723556.2020.1743807
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author McKinney, Jennifer A.
Wang, Guliang
Vasquez, Karen M.
author_facet McKinney, Jennifer A.
Wang, Guliang
Vasquez, Karen M.
author_sort McKinney, Jennifer A.
collection PubMed
description Repetitive sequences can form a variety of alternative DNA structures (non-B DNA) that can modulate transcription, replication, and repair. However, non-B DNA-forming sequences can also stimulate mutagenesis, and are enriched at mutation hotspots in human cancer genomes. Interestingly, different types of non-B DNA stimulate mutagenesis via distinct repair processing mechanisms.
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spelling pubmed-71997572020-09-28 Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins McKinney, Jennifer A. Wang, Guliang Vasquez, Karen M. Mol Cell Oncol Author's Views Repetitive sequences can form a variety of alternative DNA structures (non-B DNA) that can modulate transcription, replication, and repair. However, non-B DNA-forming sequences can also stimulate mutagenesis, and are enriched at mutation hotspots in human cancer genomes. Interestingly, different types of non-B DNA stimulate mutagenesis via distinct repair processing mechanisms. Taylor & Francis 2020-04-02 /pmc/articles/PMC7199757/ /pubmed/32391433 http://dx.doi.org/10.1080/23723556.2020.1743807 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
McKinney, Jennifer A.
Wang, Guliang
Vasquez, Karen M.
Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins
title Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins
title_full Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins
title_fullStr Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins
title_full_unstemmed Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins
title_short Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins
title_sort distinct mechanisms of mutagenic processing of alternative dna structures by repair proteins
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199757/
https://www.ncbi.nlm.nih.gov/pubmed/32391433
http://dx.doi.org/10.1080/23723556.2020.1743807
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