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Complexities of pharmacogenomic interactions in cancer
Genetic and genomic alterations drive cancer development. However, they may also constitute vulnerabilities, including increased drug sensitivity, which could be harnessed for precision medicine purposes. We discuss the highly complex pharmacogenomic interactions that are beginning to be disentangle...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199761/ https://www.ncbi.nlm.nih.gov/pubmed/32391427 http://dx.doi.org/10.1080/23723556.2020.1735910 |
| _version_ | 1783529209390432256 |
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| author | Khanna, Kum Kum Duijf, Pascal H.G. |
| author_facet | Khanna, Kum Kum Duijf, Pascal H.G. |
| author_sort | Khanna, Kum Kum |
| collection | PubMed |
| description | Genetic and genomic alterations drive cancer development. However, they may also constitute vulnerabilities, including increased drug sensitivity, which could be harnessed for precision medicine purposes. We discuss the highly complex pharmacogenomic interactions that are beginning to be disentangled and hurdles that may need to be overcome before cancer patients could benefit. |
| format | Online Article Text |
| id | pubmed-7199761 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71997612020-09-28 Complexities of pharmacogenomic interactions in cancer Khanna, Kum Kum Duijf, Pascal H.G. Mol Cell Oncol Author's Views Genetic and genomic alterations drive cancer development. However, they may also constitute vulnerabilities, including increased drug sensitivity, which could be harnessed for precision medicine purposes. We discuss the highly complex pharmacogenomic interactions that are beginning to be disentangled and hurdles that may need to be overcome before cancer patients could benefit. Taylor & Francis 2020-03-19 /pmc/articles/PMC7199761/ /pubmed/32391427 http://dx.doi.org/10.1080/23723556.2020.1735910 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Author's Views Khanna, Kum Kum Duijf, Pascal H.G. Complexities of pharmacogenomic interactions in cancer |
| title | Complexities of pharmacogenomic interactions in cancer |
| title_full | Complexities of pharmacogenomic interactions in cancer |
| title_fullStr | Complexities of pharmacogenomic interactions in cancer |
| title_full_unstemmed | Complexities of pharmacogenomic interactions in cancer |
| title_short | Complexities of pharmacogenomic interactions in cancer |
| title_sort | complexities of pharmacogenomic interactions in cancer |
| topic | Author's Views |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199761/ https://www.ncbi.nlm.nih.gov/pubmed/32391427 http://dx.doi.org/10.1080/23723556.2020.1735910 |
| work_keys_str_mv | AT khannakumkum complexitiesofpharmacogenomicinteractionsincancer AT duijfpascalhg complexitiesofpharmacogenomicinteractionsincancer |