The metabolic reprogramming and vulnerability of SF3B1 mutations

Mutations in the splicing factor 3b subunit 1 (SF3B1) gene create a neomorphic protein that disrupts RNA splicing, but the downstream consequences of this missplicing are unclear. Our recent study of isogenic human cells demonstrated that SF3B1(MUT) induces reprogramming of energy metabolism and a t...

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Detalles Bibliográficos
Autor principal: Dalton, W. Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199762/
https://www.ncbi.nlm.nih.gov/pubmed/32391415
http://dx.doi.org/10.1080/23723556.2019.1697619
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author Dalton, W. Brian
author_facet Dalton, W. Brian
author_sort Dalton, W. Brian
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description Mutations in the splicing factor 3b subunit 1 (SF3B1) gene create a neomorphic protein that disrupts RNA splicing, but the downstream consequences of this missplicing are unclear. Our recent study of isogenic human cells demonstrated that SF3B1(MUT) induces reprogramming of energy metabolism and a targetable vulnerability to deprivation of the nonessential amino acid serine.
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spelling pubmed-71997622020-09-28 The metabolic reprogramming and vulnerability of SF3B1 mutations Dalton, W. Brian Mol Cell Oncol Author's Views Mutations in the splicing factor 3b subunit 1 (SF3B1) gene create a neomorphic protein that disrupts RNA splicing, but the downstream consequences of this missplicing are unclear. Our recent study of isogenic human cells demonstrated that SF3B1(MUT) induces reprogramming of energy metabolism and a targetable vulnerability to deprivation of the nonessential amino acid serine. Taylor & Francis 2020-02-16 /pmc/articles/PMC7199762/ /pubmed/32391415 http://dx.doi.org/10.1080/23723556.2019.1697619 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Dalton, W. Brian
The metabolic reprogramming and vulnerability of SF3B1 mutations
title The metabolic reprogramming and vulnerability of SF3B1 mutations
title_full The metabolic reprogramming and vulnerability of SF3B1 mutations
title_fullStr The metabolic reprogramming and vulnerability of SF3B1 mutations
title_full_unstemmed The metabolic reprogramming and vulnerability of SF3B1 mutations
title_short The metabolic reprogramming and vulnerability of SF3B1 mutations
title_sort metabolic reprogramming and vulnerability of sf3b1 mutations
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199762/
https://www.ncbi.nlm.nih.gov/pubmed/32391415
http://dx.doi.org/10.1080/23723556.2019.1697619
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