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The metabolic reprogramming and vulnerability of SF3B1 mutations
Mutations in the splicing factor 3b subunit 1 (SF3B1) gene create a neomorphic protein that disrupts RNA splicing, but the downstream consequences of this missplicing are unclear. Our recent study of isogenic human cells demonstrated that SF3B1(MUT) induces reprogramming of energy metabolism and a t...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199762/ https://www.ncbi.nlm.nih.gov/pubmed/32391415 http://dx.doi.org/10.1080/23723556.2019.1697619 |