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Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice

OBJECTIVES: Recent investigations in humans and mouse models with lupus have revealed evidence of mitochondrial dysfunction and production of mitochondrial reactive oxygen species (mROS) in T cells and neutrophils. This can provoke numerous cellular changes including oxidation of nucleic acids, prot...

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Detalles Bibliográficos
Autores principales:	Fortner, Karen A, Blanco, Luz P, Buskiewicz, Iwona, Huang, Nick, Gibson, Pamela C, Cook, Deborah L, Pedersen, Hege L, Yuen, Peter S T, Murphy, Michael P, Perl, Andras, Kaplan, Mariana J, Budd, Ralph C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Animal Models
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199895/ https://www.ncbi.nlm.nih.gov/pubmed/32343673 http://dx.doi.org/10.1136/lupus-2020-000387

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