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Targeting mitochondrial and cytosolic substrates of TRIT1 isopentenyltransferase: Specificity determinants and tRNA-i(6)A37 profiles

The tRNA isopentenyltransferases (IPTases), which add an isopentenyl group to N(6) of A37 (i(6)A37) of certain tRNAs, are among a minority of enzymes that modify cytosolic and mitochondrial tRNAs. Pathogenic mutations to the human IPTase, TRIT1, that decrease i(6)A37 levels, cause mitochondrial insu...

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Detalles Bibliográficos
Autores principales:	Khalique, Abdul, Mattijssen, Sandy, Haddad, Alexander F., Chaudhry, Shereen, Maraia, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200024/ https://www.ncbi.nlm.nih.gov/pubmed/32324744 http://dx.doi.org/10.1371/journal.pgen.1008330

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