Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia

We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyalur...

Descripción completa

Detalles Bibliográficos
Autores principales: Cruz, Rachel J, Dasso, Joseph F, Duff, Carla, Krasnopero, Diane, Long, Zsofia, Ellison, Maryssa, Nieves, Daime, Sriaroon, Panida, Asante-Korang, Alfred, Walter, Jolan E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Id Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200086/
https://www.ncbi.nlm.nih.gov/pubmed/32391400
http://dx.doi.org/10.1093/ofid/ofaa076
Descripción
Sumario:We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyaluronidase-facilitated subcutaneous immunoglobulin (HD-SCIG-Hy). We discuss the advantages of HD-SCIG-Hy vs HD-IVIG treatment for similar cases.

Ejemplares similares