Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia

We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyalur...

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Autores principales: Cruz, Rachel J, Dasso, Joseph F, Duff, Carla, Krasnopero, Diane, Long, Zsofia, Ellison, Maryssa, Nieves, Daime, Sriaroon, Panida, Asante-Korang, Alfred, Walter, Jolan E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Id Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200086/
https://www.ncbi.nlm.nih.gov/pubmed/32391400
http://dx.doi.org/10.1093/ofid/ofaa076
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author Cruz, Rachel J
Dasso, Joseph F
Duff, Carla
Krasnopero, Diane
Long, Zsofia
Ellison, Maryssa
Nieves, Daime
Sriaroon, Panida
Asante-Korang, Alfred
Walter, Jolan E
author_facet Cruz, Rachel J
Dasso, Joseph F
Duff, Carla
Krasnopero, Diane
Long, Zsofia
Ellison, Maryssa
Nieves, Daime
Sriaroon, Panida
Asante-Korang, Alfred
Walter, Jolan E
author_sort Cruz, Rachel J
collection PubMed
description We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyaluronidase-facilitated subcutaneous immunoglobulin (HD-SCIG-Hy). We discuss the advantages of HD-SCIG-Hy vs HD-IVIG treatment for similar cases.
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spelling pubmed-72000862020-05-08 Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia Cruz, Rachel J Dasso, Joseph F Duff, Carla Krasnopero, Diane Long, Zsofia Ellison, Maryssa Nieves, Daime Sriaroon, Panida Asante-Korang, Alfred Walter, Jolan E Open Forum Infect Dis Id Cases We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyaluronidase-facilitated subcutaneous immunoglobulin (HD-SCIG-Hy). We discuss the advantages of HD-SCIG-Hy vs HD-IVIG treatment for similar cases. Oxford University Press 2020-03-12 /pmc/articles/PMC7200086/ /pubmed/32391400 http://dx.doi.org/10.1093/ofid/ofaa076 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Id Cases
Cruz, Rachel J
Dasso, Joseph F
Duff, Carla
Krasnopero, Diane
Long, Zsofia
Ellison, Maryssa
Nieves, Daime
Sriaroon, Panida
Asante-Korang, Alfred
Walter, Jolan E
Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia
title Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia
title_full Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia
title_fullStr Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia
title_full_unstemmed Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia
title_short Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia
title_sort hyaluronidase-facilitated high-dose subcutaneous igg effectively controls parvovirus b19 infection in a pediatric cardiac transplant patient with severe t-cell lymphopenia
topic Id Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200086/
https://www.ncbi.nlm.nih.gov/pubmed/32391400
http://dx.doi.org/10.1093/ofid/ofaa076
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