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Controlling gene activation by enhancers through a drug-inducible topological insulator

While regulation of gene-enhancer interaction is intensively studied, its application remains limited. Here, we reconstituted arrays of CTCF-binding sites and devised a synthetic topological insulator with tetO for chromatin-engineering (STITCH). By coupling STITCH with tetR linked to the KRAB domai...

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Detalles Bibliográficos
Autores principales:	Tsujimura, Taro, Takase, Osamu, Yoshikawa, Masahiro, Sano, Etsuko, Hayashi, Matsuhiko, Hoshi, Kazuto, Takato, Tsuyoshi, Toyoda, Atsushi, Okano, Hideyuki, Hishikawa, Keiichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200164/ https://www.ncbi.nlm.nih.gov/pubmed/32369019 http://dx.doi.org/10.7554/eLife.47980

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