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Immunology of COVID-19: Current State of the Science
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200337/ https://www.ncbi.nlm.nih.gov/pubmed/32505227 http://dx.doi.org/10.1016/j.immuni.2020.05.002 |
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| author | Vabret, Nicolas Britton, Graham J. Gruber, Conor Hegde, Samarth Kim, Joel Kuksin, Maria Levantovsky, Rachel Malle, Louise Moreira, Alvaro Park, Matthew D. Pia, Luisanna Risson, Emma Saffern, Miriam Salomé, Bérengère Esai Selvan, Myvizhi Spindler, Matthew P. Tan, Jessica van der Heide, Verena Gregory, Jill K. Alexandropoulos, Konstantina Bhardwaj, Nina Brown, Brian D. Greenbaum, Benjamin Gümüş, Zeynep H. Homann, Dirk Horowitz, Amir Kamphorst, Alice O. Curotto de Lafaille, Maria A. Mehandru, Saurabh Merad, Miriam Samstein, Robert M. |
| author_facet | Vabret, Nicolas Britton, Graham J. Gruber, Conor Hegde, Samarth Kim, Joel Kuksin, Maria Levantovsky, Rachel Malle, Louise Moreira, Alvaro Park, Matthew D. Pia, Luisanna Risson, Emma Saffern, Miriam Salomé, Bérengère Esai Selvan, Myvizhi Spindler, Matthew P. Tan, Jessica van der Heide, Verena Gregory, Jill K. Alexandropoulos, Konstantina Bhardwaj, Nina Brown, Brian D. Greenbaum, Benjamin Gümüş, Zeynep H. Homann, Dirk Horowitz, Amir Kamphorst, Alice O. Curotto de Lafaille, Maria A. Mehandru, Saurabh Merad, Miriam Samstein, Robert M. |
| author_sort | Vabret, Nicolas |
| collection | PubMed |
| description | The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection. |
| format | Online Article Text |
| id | pubmed-7200337 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Elsevier Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-72003372020-05-06 Immunology of COVID-19: Current State of the Science Vabret, Nicolas Britton, Graham J. Gruber, Conor Hegde, Samarth Kim, Joel Kuksin, Maria Levantovsky, Rachel Malle, Louise Moreira, Alvaro Park, Matthew D. Pia, Luisanna Risson, Emma Saffern, Miriam Salomé, Bérengère Esai Selvan, Myvizhi Spindler, Matthew P. Tan, Jessica van der Heide, Verena Gregory, Jill K. Alexandropoulos, Konstantina Bhardwaj, Nina Brown, Brian D. Greenbaum, Benjamin Gümüş, Zeynep H. Homann, Dirk Horowitz, Amir Kamphorst, Alice O. Curotto de Lafaille, Maria A. Mehandru, Saurabh Merad, Miriam Samstein, Robert M. Immunity Review The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection. Elsevier Inc. 2020-06-16 2020-05-06 /pmc/articles/PMC7200337/ /pubmed/32505227 http://dx.doi.org/10.1016/j.immuni.2020.05.002 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Review Vabret, Nicolas Britton, Graham J. Gruber, Conor Hegde, Samarth Kim, Joel Kuksin, Maria Levantovsky, Rachel Malle, Louise Moreira, Alvaro Park, Matthew D. Pia, Luisanna Risson, Emma Saffern, Miriam Salomé, Bérengère Esai Selvan, Myvizhi Spindler, Matthew P. Tan, Jessica van der Heide, Verena Gregory, Jill K. Alexandropoulos, Konstantina Bhardwaj, Nina Brown, Brian D. Greenbaum, Benjamin Gümüş, Zeynep H. Homann, Dirk Horowitz, Amir Kamphorst, Alice O. Curotto de Lafaille, Maria A. Mehandru, Saurabh Merad, Miriam Samstein, Robert M. Immunology of COVID-19: Current State of the Science |
| title | Immunology of COVID-19: Current State of the Science |
| title_full | Immunology of COVID-19: Current State of the Science |
| title_fullStr | Immunology of COVID-19: Current State of the Science |
| title_full_unstemmed | Immunology of COVID-19: Current State of the Science |
| title_short | Immunology of COVID-19: Current State of the Science |
| title_sort | immunology of covid-19: current state of the science |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200337/ https://www.ncbi.nlm.nih.gov/pubmed/32505227 http://dx.doi.org/10.1016/j.immuni.2020.05.002 |
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