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Enhanced electrocardiographic monitoring of patients with Coronavirus Disease 2019

BACKGROUND: Many of the drugs being used in the treatment of the ongoing pandemic coronavirus disease 2019 (COVID-19) are associated with QT prolongation. Expert guidance supports electrocardiographic (ECG) monitoring to optimize patient safety. OBJECTIVE: The purpose of this study was to establish...

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Detalles Bibliográficos
Autores principales: Jain, Shashank, Workman, Virginia, Ganeshan, Raj, Obasare, Edinrin R., Burr, Alicia, DeBiasi, Ralph M., Freeman, James V., Akar, Joseph, Lampert, Rachel, Rosenfeld, Lynda E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Heart Rhythm Society. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200355/
https://www.ncbi.nlm.nih.gov/pubmed/32387247
http://dx.doi.org/10.1016/j.hrthm.2020.04.047
Descripción
Sumario:BACKGROUND: Many of the drugs being used in the treatment of the ongoing pandemic coronavirus disease 2019 (COVID-19) are associated with QT prolongation. Expert guidance supports electrocardiographic (ECG) monitoring to optimize patient safety. OBJECTIVE: The purpose of this study was to establish an enhanced process for ECG monitoring of patients being treated for COVID-19. METHODS: We created a Situation Background Assessment Recommendation tool identifying the indication for ECGs in patients with COVID-19 and tagged these ECGs to ensure prompt over reading and identification of those with QT prolongation (corrected QT interval > 470 ms for QRS duration ≤ 120 ms; corrected QT interval > 500 ms for QRS duration > 120 ms). This triggered a phone call from the electrophysiology service to the primary team to provide management guidance and a formal consultation if requested. RESULTS: During a 2-week period, we reviewed 2006 ECGs, corresponding to 524 unique patients, of whom 103 (19.7%) met the Situation Background Assessment Recommendation tool–defined criteria for QT prolongation. Compared with those without QT prolongation, these patients were more often in the intensive care unit (60 [58.3%] vs 149 [35.4%]) and more likely to be intubated (32 [31.1%] vs 76 [18.1%]). Fifty patients with QT prolongation (48.5%) had electrolyte abnormalities, 98 (95.1%) were on COVID-19–related QT-prolonging medications, and 62 (60.2%) were on 1–4 additional non-COVID-19–related QT-prolonging drugs. Electrophysiology recommendations were given to limit modifiable risk factors. No patient developed torsades de pointes. CONCLUSION: This process functioned efficiently, identified a high percentage of patients with QT prolongation, and led to relevant interventions. Arrhythmias were rare. No patient developed torsades de pointes.