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MultiHance as a contrast alternative for Gadovist allergic patients
The dramatic rise in the use of contrast agents for diagnostic imaging within the last decade has largely contributed to the effectiveness of MR imaging, however even with the use of prophylaxis, adverse reactions to contrast, including anaphylaxis, still occur. We describe the case of a 46-year-old...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200611/ https://www.ncbi.nlm.nih.gov/pubmed/32382365 http://dx.doi.org/10.1016/j.radcr.2020.04.023 |
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author | Malone, Janna Tiberi, David Frankish, Charles Nguyen, Thanh Sinclair, John Malone, Shawn |
author_facet | Malone, Janna Tiberi, David Frankish, Charles Nguyen, Thanh Sinclair, John Malone, Shawn |
author_sort | Malone, Janna |
collection | PubMed |
description | The dramatic rise in the use of contrast agents for diagnostic imaging within the last decade has largely contributed to the effectiveness of MR imaging, however even with the use of prophylaxis, adverse reactions to contrast, including anaphylaxis, still occur. We describe the case of a 46-year-old female patient with a hemangiopericytoma requiring ongoing contrast MR surveillance, and a documented anaphylactic reaction to Gadovist (gadobutrol injection) despite premedication. Allergy testing was positive to intradermal undiluted Gadovist, confirming an IgE-mediated Gadovist allergy, with subsequent skin testing by prick and intradermal negative to undiluted MultiHance. She went on to receive MultiHance prior to her subsequent MRI scans without clinical reaction and without premedication, demonstrating that there may be superior alternatives to traditionally used gadolinium dyes in patients with moderate to severe reactions, and warrants further investigation into the anaphylactoid characteristics between the different gadolinium-based contrast agents. |
format | Online Article Text |
id | pubmed-7200611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-72006112020-05-07 MultiHance as a contrast alternative for Gadovist allergic patients Malone, Janna Tiberi, David Frankish, Charles Nguyen, Thanh Sinclair, John Malone, Shawn Radiol Case Rep Complications of Therapy The dramatic rise in the use of contrast agents for diagnostic imaging within the last decade has largely contributed to the effectiveness of MR imaging, however even with the use of prophylaxis, adverse reactions to contrast, including anaphylaxis, still occur. We describe the case of a 46-year-old female patient with a hemangiopericytoma requiring ongoing contrast MR surveillance, and a documented anaphylactic reaction to Gadovist (gadobutrol injection) despite premedication. Allergy testing was positive to intradermal undiluted Gadovist, confirming an IgE-mediated Gadovist allergy, with subsequent skin testing by prick and intradermal negative to undiluted MultiHance. She went on to receive MultiHance prior to her subsequent MRI scans without clinical reaction and without premedication, demonstrating that there may be superior alternatives to traditionally used gadolinium dyes in patients with moderate to severe reactions, and warrants further investigation into the anaphylactoid characteristics between the different gadolinium-based contrast agents. Elsevier 2020-04-30 /pmc/articles/PMC7200611/ /pubmed/32382365 http://dx.doi.org/10.1016/j.radcr.2020.04.023 Text en © 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Complications of Therapy Malone, Janna Tiberi, David Frankish, Charles Nguyen, Thanh Sinclair, John Malone, Shawn MultiHance as a contrast alternative for Gadovist allergic patients |
title | MultiHance as a contrast alternative for Gadovist allergic patients |
title_full | MultiHance as a contrast alternative for Gadovist allergic patients |
title_fullStr | MultiHance as a contrast alternative for Gadovist allergic patients |
title_full_unstemmed | MultiHance as a contrast alternative for Gadovist allergic patients |
title_short | MultiHance as a contrast alternative for Gadovist allergic patients |
title_sort | multihance as a contrast alternative for gadovist allergic patients |
topic | Complications of Therapy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200611/ https://www.ncbi.nlm.nih.gov/pubmed/32382365 http://dx.doi.org/10.1016/j.radcr.2020.04.023 |
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