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The role of SUMOylation during development
During the development of multicellular organisms, transcriptional regulation plays an important role in the control of cell growth, differentiation and morphogenesis. SUMOylation is a reversible post-translational process involved in transcriptional regulation through the modification of transcript...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200636/ https://www.ncbi.nlm.nih.gov/pubmed/32311032 http://dx.doi.org/10.1042/BST20190390 |
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author | Talamillo, Ana Barroso-Gomila, Orhi Giordano, Immacolata Ajuria, Leiore Grillo, Marco Mayor, Ugo Barrio, Rosa |
author_facet | Talamillo, Ana Barroso-Gomila, Orhi Giordano, Immacolata Ajuria, Leiore Grillo, Marco Mayor, Ugo Barrio, Rosa |
author_sort | Talamillo, Ana |
collection | PubMed |
description | During the development of multicellular organisms, transcriptional regulation plays an important role in the control of cell growth, differentiation and morphogenesis. SUMOylation is a reversible post-translational process involved in transcriptional regulation through the modification of transcription factors and through chromatin remodelling (either modifying chromatin remodelers or acting as a ‘molecular glue’ by promoting recruitment of chromatin regulators). SUMO modification results in changes in the activity, stability, interactions or localization of its substrates, which affects cellular processes such as cell cycle progression, DNA maintenance and repair or nucleocytoplasmic transport. This review focuses on the role of SUMO machinery and the modification of target proteins during embryonic development and organogenesis of animals, from invertebrates to mammals. |
format | Online Article Text |
id | pubmed-7200636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72006362020-05-13 The role of SUMOylation during development Talamillo, Ana Barroso-Gomila, Orhi Giordano, Immacolata Ajuria, Leiore Grillo, Marco Mayor, Ugo Barrio, Rosa Biochem Soc Trans Review Articles During the development of multicellular organisms, transcriptional regulation plays an important role in the control of cell growth, differentiation and morphogenesis. SUMOylation is a reversible post-translational process involved in transcriptional regulation through the modification of transcription factors and through chromatin remodelling (either modifying chromatin remodelers or acting as a ‘molecular glue’ by promoting recruitment of chromatin regulators). SUMO modification results in changes in the activity, stability, interactions or localization of its substrates, which affects cellular processes such as cell cycle progression, DNA maintenance and repair or nucleocytoplasmic transport. This review focuses on the role of SUMO machinery and the modification of target proteins during embryonic development and organogenesis of animals, from invertebrates to mammals. Portland Press Ltd. 2020-04-29 2020-04-20 /pmc/articles/PMC7200636/ /pubmed/32311032 http://dx.doi.org/10.1042/BST20190390 Text en © 2020 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Articles Talamillo, Ana Barroso-Gomila, Orhi Giordano, Immacolata Ajuria, Leiore Grillo, Marco Mayor, Ugo Barrio, Rosa The role of SUMOylation during development |
title | The role of SUMOylation during development |
title_full | The role of SUMOylation during development |
title_fullStr | The role of SUMOylation during development |
title_full_unstemmed | The role of SUMOylation during development |
title_short | The role of SUMOylation during development |
title_sort | role of sumoylation during development |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200636/ https://www.ncbi.nlm.nih.gov/pubmed/32311032 http://dx.doi.org/10.1042/BST20190390 |
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