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The role of SUMOylation during development

During the development of multicellular organisms, transcriptional regulation plays an important role in the control of cell growth, differentiation and morphogenesis. SUMOylation is a reversible post-translational process involved in transcriptional regulation through the modification of transcript...

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Detalles Bibliográficos
Autores principales: Talamillo, Ana, Barroso-Gomila, Orhi, Giordano, Immacolata, Ajuria, Leiore, Grillo, Marco, Mayor, Ugo, Barrio, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200636/
https://www.ncbi.nlm.nih.gov/pubmed/32311032
http://dx.doi.org/10.1042/BST20190390
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author Talamillo, Ana
Barroso-Gomila, Orhi
Giordano, Immacolata
Ajuria, Leiore
Grillo, Marco
Mayor, Ugo
Barrio, Rosa
author_facet Talamillo, Ana
Barroso-Gomila, Orhi
Giordano, Immacolata
Ajuria, Leiore
Grillo, Marco
Mayor, Ugo
Barrio, Rosa
author_sort Talamillo, Ana
collection PubMed
description During the development of multicellular organisms, transcriptional regulation plays an important role in the control of cell growth, differentiation and morphogenesis. SUMOylation is a reversible post-translational process involved in transcriptional regulation through the modification of transcription factors and through chromatin remodelling (either modifying chromatin remodelers or acting as a ‘molecular glue’ by promoting recruitment of chromatin regulators). SUMO modification results in changes in the activity, stability, interactions or localization of its substrates, which affects cellular processes such as cell cycle progression, DNA maintenance and repair or nucleocytoplasmic transport. This review focuses on the role of SUMO machinery and the modification of target proteins during embryonic development and organogenesis of animals, from invertebrates to mammals.
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spelling pubmed-72006362020-05-13 The role of SUMOylation during development Talamillo, Ana Barroso-Gomila, Orhi Giordano, Immacolata Ajuria, Leiore Grillo, Marco Mayor, Ugo Barrio, Rosa Biochem Soc Trans Review Articles During the development of multicellular organisms, transcriptional regulation plays an important role in the control of cell growth, differentiation and morphogenesis. SUMOylation is a reversible post-translational process involved in transcriptional regulation through the modification of transcription factors and through chromatin remodelling (either modifying chromatin remodelers or acting as a ‘molecular glue’ by promoting recruitment of chromatin regulators). SUMO modification results in changes in the activity, stability, interactions or localization of its substrates, which affects cellular processes such as cell cycle progression, DNA maintenance and repair or nucleocytoplasmic transport. This review focuses on the role of SUMO machinery and the modification of target proteins during embryonic development and organogenesis of animals, from invertebrates to mammals. Portland Press Ltd. 2020-04-29 2020-04-20 /pmc/articles/PMC7200636/ /pubmed/32311032 http://dx.doi.org/10.1042/BST20190390 Text en © 2020 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Articles
Talamillo, Ana
Barroso-Gomila, Orhi
Giordano, Immacolata
Ajuria, Leiore
Grillo, Marco
Mayor, Ugo
Barrio, Rosa
The role of SUMOylation during development
title The role of SUMOylation during development
title_full The role of SUMOylation during development
title_fullStr The role of SUMOylation during development
title_full_unstemmed The role of SUMOylation during development
title_short The role of SUMOylation during development
title_sort role of sumoylation during development
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200636/
https://www.ncbi.nlm.nih.gov/pubmed/32311032
http://dx.doi.org/10.1042/BST20190390
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