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Human host defense peptide LL-37 facilitates double-stranded RNA pro-inflammatory signaling through up-regulation of TLR3 expression in vascular smooth muscle cells

OBJECTIVE: The importance of human host defense peptide LL-37 in vascular innate immunity is not understood. Here, we assess the impact of LL-37 on double-stranded RNA (dsRNA) signaling in human vascular smooth muscle cells. MATERIALS AND METHODS: Cellular import of LL-37 and synthetic dsRNA (poly I...

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Detalles Bibliográficos
Autores principales:	Dahl, Sara, Cerps, Samuel, Rippe, Catarina, Swärd, Karl, Uller, Lena, Svensson, Daniel, Nilsson, Bengt-Olof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Original Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200649/ https://www.ncbi.nlm.nih.gov/pubmed/32221618 http://dx.doi.org/10.1007/s00011-020-01340-2

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