Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia

Mycobacterium tuberculosis (MTB) is commonly used as a model to study pathogenicity and multiple drug resistance in bacteria. These MTB characteristics are highly dependent on the evolution and phylogeography of the bacterium. In this paper, we describe 15 new genomes of multidrug-resistant MTB (MDR...

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Autores principales: Tan, Joon Liang, Simbun, Alfred, Chan, Kok-Gan, Ngeow, Yun Fong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Data Descriptor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200664/
https://www.ncbi.nlm.nih.gov/pubmed/32371951
http://dx.doi.org/10.1038/s41597-020-0475-x
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author Tan, Joon Liang
Simbun, Alfred
Chan, Kok-Gan
Ngeow, Yun Fong
author_facet Tan, Joon Liang
Simbun, Alfred
Chan, Kok-Gan
Ngeow, Yun Fong
author_sort Tan, Joon Liang
collection PubMed
description Mycobacterium tuberculosis (MTB) is commonly used as a model to study pathogenicity and multiple drug resistance in bacteria. These MTB characteristics are highly dependent on the evolution and phylogeography of the bacterium. In this paper, we describe 15 new genomes of multidrug-resistant MTB (MDRTB) from Malaysia. The assessments and annotations on the genome assemblies suggest that strain differences are due to lineages and horizontal gene transfer during the course of evolution. The genomes show mutations listed in current drug resistance databases and global MTB collections. This genome data will augment existing information available for comparative genomic studies to understand MTB drug resistance mechanisms and evolution.
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spelling pubmed-72006642020-05-06 Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia Tan, Joon Liang Simbun, Alfred Chan, Kok-Gan Ngeow, Yun Fong Sci Data Data Descriptor Mycobacterium tuberculosis (MTB) is commonly used as a model to study pathogenicity and multiple drug resistance in bacteria. These MTB characteristics are highly dependent on the evolution and phylogeography of the bacterium. In this paper, we describe 15 new genomes of multidrug-resistant MTB (MDRTB) from Malaysia. The assessments and annotations on the genome assemblies suggest that strain differences are due to lineages and horizontal gene transfer during the course of evolution. The genomes show mutations listed in current drug resistance databases and global MTB collections. This genome data will augment existing information available for comparative genomic studies to understand MTB drug resistance mechanisms and evolution. Nature Publishing Group UK 2020-05-05 /pmc/articles/PMC7200664/ /pubmed/32371951 http://dx.doi.org/10.1038/s41597-020-0475-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files associated with this article.
spellingShingle Data Descriptor
Tan, Joon Liang
Simbun, Alfred
Chan, Kok-Gan
Ngeow, Yun Fong
Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia
title Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia
title_full Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia
title_fullStr Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia
title_full_unstemmed Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia
title_short Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia
title_sort genome sequence analysis of multidrug-resistant mycobacterium tuberculosis from malaysia
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200664/
https://www.ncbi.nlm.nih.gov/pubmed/32371951
http://dx.doi.org/10.1038/s41597-020-0475-x
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AT ngeowyunfong genomesequenceanalysisofmultidrugresistantmycobacteriumtuberculosisfrommalaysia

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