Extrahepatic cholangiocyte obstruction is mediated by decreased glutathione, Wnt and Notch signaling pathways in a toxic model of biliary atresia

Biliary atresia is a neonatal liver disease with extrahepatic bile duct obstruction and progressive liver fibrosis. The etiology and pathogenesis of the disease are unknown. We previously identified a plant toxin, biliatresone, responsible for biliary atresia in naturally-occurring animal models, th...

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Detalles Bibliográficos
Autores principales: Fried, Sophia, Gilboa, Dafna, Har-Zahav, Adi, Lavrut, Pierre-Marie, Du, Yu, Karjoo, Sara, Russo, Pierre, Shamir, Raanan, Wells, Rebecca G., Waisbourd-Zinman, Orith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200694/
https://www.ncbi.nlm.nih.gov/pubmed/32371929
http://dx.doi.org/10.1038/s41598-020-64503-5

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