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Correlation between total sperm count and sperm motility and pregnancy rate in couples undergoing intrauterine insemination

The frequency and significance of sterility is increasing due to different socio-demographic factors in the industrialized countries. At the same time, the patients’ demand for more natural and less invasive fertility treatments is increasing. The most common method used in subfertility is intrauter...

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Autores principales: Findeklee, Sebastian, Radosa, Julia Caroline, Radosa, Marc Philipp, Hammadeh, Mohamad Eid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200727/
https://www.ncbi.nlm.nih.gov/pubmed/32371917
http://dx.doi.org/10.1038/s41598-020-64578-0
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author Findeklee, Sebastian
Radosa, Julia Caroline
Radosa, Marc Philipp
Hammadeh, Mohamad Eid
author_facet Findeklee, Sebastian
Radosa, Julia Caroline
Radosa, Marc Philipp
Hammadeh, Mohamad Eid
author_sort Findeklee, Sebastian
collection PubMed
description The frequency and significance of sterility is increasing due to different socio-demographic factors in the industrialized countries. At the same time, the patients’ demand for more natural and less invasive fertility treatments is increasing. The most common method used in subfertility is intrauterine insemination (IUI). Retrospectively, the data from the patients were analyzed, in which at least one insemination and a maximum of eight inseminations were performed in the last five years (observation period 01.01.2014–31.12.2018) at the Women’s University Hospital Homburg. The primary endpoint was the onset of a clinical pregnancy. Clinical pregnancy was correlated with the partner’s total sperm count (sperm density in millions), sperm concentration and motility during insemination. These three parameters were evaluated according the World Health Organization (WHO) 2010 guidelines. The results of the spermiograms were correlated with clinical pregnancy outcome. The data were examined for 138 women with sterility, in which a total of 345 inseminations were performed (median 2.5 per woman, range 8 inseminations). There was no correlation found between spermiogram parameters and pregnancy probability in any of the inseminations. After 5 inseminations no further pregnancy occurred. The present study showed no correlation between the conception probability of intrauterine insemination (IUI) and the total sperm count/concentration/motility. After the sixth IUI, we no longer found conceptions in our patient collective. Therefore, data from this study indicate that intrauterine inseminations can be performed at all severity levels of oligoasthenozoospermia. However, the treatment should be limited to five attempts.
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spelling pubmed-72007272020-05-12 Correlation between total sperm count and sperm motility and pregnancy rate in couples undergoing intrauterine insemination Findeklee, Sebastian Radosa, Julia Caroline Radosa, Marc Philipp Hammadeh, Mohamad Eid Sci Rep Article The frequency and significance of sterility is increasing due to different socio-demographic factors in the industrialized countries. At the same time, the patients’ demand for more natural and less invasive fertility treatments is increasing. The most common method used in subfertility is intrauterine insemination (IUI). Retrospectively, the data from the patients were analyzed, in which at least one insemination and a maximum of eight inseminations were performed in the last five years (observation period 01.01.2014–31.12.2018) at the Women’s University Hospital Homburg. The primary endpoint was the onset of a clinical pregnancy. Clinical pregnancy was correlated with the partner’s total sperm count (sperm density in millions), sperm concentration and motility during insemination. These three parameters were evaluated according the World Health Organization (WHO) 2010 guidelines. The results of the spermiograms were correlated with clinical pregnancy outcome. The data were examined for 138 women with sterility, in which a total of 345 inseminations were performed (median 2.5 per woman, range 8 inseminations). There was no correlation found between spermiogram parameters and pregnancy probability in any of the inseminations. After 5 inseminations no further pregnancy occurred. The present study showed no correlation between the conception probability of intrauterine insemination (IUI) and the total sperm count/concentration/motility. After the sixth IUI, we no longer found conceptions in our patient collective. Therefore, data from this study indicate that intrauterine inseminations can be performed at all severity levels of oligoasthenozoospermia. However, the treatment should be limited to five attempts. Nature Publishing Group UK 2020-05-05 /pmc/articles/PMC7200727/ /pubmed/32371917 http://dx.doi.org/10.1038/s41598-020-64578-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Findeklee, Sebastian
Radosa, Julia Caroline
Radosa, Marc Philipp
Hammadeh, Mohamad Eid
Correlation between total sperm count and sperm motility and pregnancy rate in couples undergoing intrauterine insemination
title Correlation between total sperm count and sperm motility and pregnancy rate in couples undergoing intrauterine insemination
title_full Correlation between total sperm count and sperm motility and pregnancy rate in couples undergoing intrauterine insemination
title_fullStr Correlation between total sperm count and sperm motility and pregnancy rate in couples undergoing intrauterine insemination
title_full_unstemmed Correlation between total sperm count and sperm motility and pregnancy rate in couples undergoing intrauterine insemination
title_short Correlation between total sperm count and sperm motility and pregnancy rate in couples undergoing intrauterine insemination
title_sort correlation between total sperm count and sperm motility and pregnancy rate in couples undergoing intrauterine insemination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200727/
https://www.ncbi.nlm.nih.gov/pubmed/32371917
http://dx.doi.org/10.1038/s41598-020-64578-0
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