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A high-resolution description of β(1)-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR
Signal transmission and regulation of G-protein-coupled receptors (GPCRs) by extra- and intracellular ligands occurs via modulation of complex conformational equilibria, but their exact kinetic details and underlying atomic mechanisms are unknown. Here we quantified these dynamic equilibria in the β...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200737/ https://www.ncbi.nlm.nih.gov/pubmed/32371991 http://dx.doi.org/10.1038/s41467-020-15864-y |