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A high-resolution description of β(1)-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR

Signal transmission and regulation of G-protein-coupled receptors (GPCRs) by extra- and intracellular ligands occurs via modulation of complex conformational equilibria, but their exact kinetic details and underlying atomic mechanisms are unknown. Here we quantified these dynamic equilibria in the β...

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Detalles Bibliográficos
Autores principales:	Grahl, Anne, Abiko, Layara Akemi, Isogai, Shin, Sharpe, Timothy, Grzesiek, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200737/ https://www.ncbi.nlm.nih.gov/pubmed/32371991 http://dx.doi.org/10.1038/s41467-020-15864-y

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