N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1 to generate N-GSDMD fragments. N-GSDMD then oligomerizes in the plasma membrane (PM) to form pores that increase membrane permeability, leading to pyroptosis and IL-1β release. In contrast, we report that although N-GS...

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Detalles Bibliográficos
Autores principales: Karmakar, Mausita, Minns, Martin, Greenberg, Elyse N., Diaz-Aponte, Jose, Pestonjamasp, Kersi, Johnson, Jennifer L., Rathkey, Joseph K., Abbott, Derek W., Wang, Kun, Shao, Feng, Catz, Sergio D., Dubyak, George R., Pearlman, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200749/
https://www.ncbi.nlm.nih.gov/pubmed/32371889
http://dx.doi.org/10.1038/s41467-020-16043-9

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