Cargando…

Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice

Splicing factor SRSF2 is frequently mutated or up-regulated in human cancers. Here, we observe that hepatocyte-specific deletion of Srsf2 trigger development of hepatocellular carcinoma (HCC) in mice, which also involves inflammation and fibrosis. Importantly, we find that, when compensatory hepatoc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Chang, Shen, Lei, Yuan, Wei, Liu, Yuguo, Guo, Ruochen, Luo, Yangjun, Zhan, Zheng, Xie, Zhiqin, Wu, Guohao, Wu, Wenwu, Feng, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200752/ https://www.ncbi.nlm.nih.gov/pubmed/32372053 http://dx.doi.org/10.1038/s42003-020-0893-5

Ejemplares similares

Splicing Factor SRSF1 Is Essential for Satellite Cell Proliferation and Postnatal Maturation of Neuromuscular Junctions in Mice
por: Liu, Yuguo, et al.
Publicado: (2020)

The long noncoding RNA MALAT1 modulates adipose loss in cancer-associated cachexia by suppressing adipogenesis through PPAR-γ
por: Han, Jun, et al.
Publicado: (2021)

Genome-wide analysis of SRSF10-regulated alternative splicing by deep sequencing of chicken transcriptome
por: Zhou, Xuexia, et al.
Publicado: (2014)

Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation
por: Zhou, Xuexia, et al.
Publicado: (2014)

SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing
por: Liu, Wenbo, et al.
Publicado: (2022)

Single‐Cell RNA Sequencing Reveals Heterogeneity of Myf5‐Derived Cells and Altered Myogenic Fate in the Absence of SRSF2
por: Guo, Ruochen, et al.
Publicado: (2022)

SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis
por: Fu, Yu, et al.
Publicado: (2013)

Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells
por: Gautrey, Hannah L., et al.
Publicado: (2012)

SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex
por: Li, Junjie, et al.
Publicado: (2023)

Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3
por: Ke, Hao, et al.
Publicado: (2018)

SRSF7 and SRSF3 depend on RNA sequencing motifs and secondary structures to regulate Microprocessor
por: Le, Minh Ngoc, et al.
Publicado: (2023)

SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis
por: Liu, Xiaoming, et al.
Publicado: (2022)

Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death
por: Arif, Waqar, et al.
Publicado: (2023)

Loss of Splicing Factor SRSF3 Impairs Lipophagy Through Ubiquitination and Degradation of Syntaxin17 in Hepatocytes
por: Li, Yun, et al.
Publicado: (2023)

Sequence-dependent recruitment of SRSF1 and SRSF7 to intronless lncRNA NKILA promotes nuclear export via the TREX/TAP pathway
por: Khan, Misbah, et al.
Publicado: (2021)

Oncogenic SRSF3 in health and diseases
por: Jia, Rong, et al.
Publicado: (2023)

Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and browning
por: Han, Jun, et al.
Publicado: (2018)

Relative strength of 5’ splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA
por: Choi, Namjeong, et al.
Publicado: (2021)

SRSF1-mediated alternative splicing is required for spermatogenesis
por: Lei, Wen-Long, et al.
Publicado: (2023)

Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice
por: Kadota, Yosuke, et al.
Publicado: (2020)

Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice
por: Kadota, Yosuke, et al.
Publicado: (2020)

Phosphorylation of SRSF1 is modulated by replicational stress
por: Leva, Valentina, et al.
Publicado: (2012)

SRSF2 mutations in myelodysplasia/myeloproliferative neoplasms
por: Aujla, Amandeep, et al.
Publicado: (2018)

Loss of SRSF3 in Cardiomyocytes Leads to Decapping of Contraction-Related mRNAs and Severe Systolic Dysfunction
por: Ortiz-Sánchez, Paula, et al.
Publicado: (2019)

SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm
por: Yang, Yue, et al.
Publicado: (2023)

A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis
por: Zhang, Yawen, et al.
Publicado: (2022)

SRSF3 and SRSF7 modulate 3′UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels
por: Schwich, Oliver Daniel, et al.
Publicado: (2021)

SRSF2 is required for mRNA splicing during spermatogenesis
por: Lei, Wen-Long, et al.
Publicado: (2023)

Hepatic progenitor cell activation is induced by the depletion of the gut microbiome in mice
por: Wang, Fei, et al.
Publicado: (2019)

SRSF1 inhibition of HIV-1 gene expression
por: Paz, Sean, et al.
Publicado: (2015)

Splicing factor SRSF6 mediates pleural fibrosis
por: Liang, Li-Mei, et al.
Publicado: (2021)

Splicing factor SRSF2-centric gene regulation
por: Li, Kun, et al.
Publicado: (2021)

Targeting Splicing Factor SRSF6 for Cancer Therapy
por: She, Wenting, et al.
Publicado: (2021)

Loss of Numb promotes hepatic progenitor expansion and intrahepatic cholangiocarcinoma by enhancing Notch signaling
por: Shu, Yuke, et al.
Publicado: (2021)

Proteasome-Mediated Proteolysis of SRSF5 Splicing Factor Intriguingly Co-occurs with SRSF5 mRNA Upregulation during Late Erythroid Differentiation
por: Breig, Osman, et al.
Publicado: (2013)

Myeloid Disease Mutations of Splicing Factor SRSF2 Cause G2‐M Arrest and Skewed Differentiation of Human Hematopoietic Stem and Progenitor Cells
por: Bapat, Aditi, et al.
Publicado: (2018)

Long Non-coding RNA T-uc.189 Modulates Neural Progenitor Cell Fate by Regulating Srsf3 During Mouse Cerebral Cortex Development
por: Zhang, Meng, et al.
Publicado: (2021)

SRSF1 regulates primordial follicle formation and number determination during meiotic prophase I
por: Sun, Longjie, et al.
Publicado: (2023)

THE SPLICING FACTOR SRSF1 REGULATES APOPTOSIS AND PROLIFERATION TO PROMOTE MAMMARY EPITHELIAL CELL TRANSFORMATION
por: Anczuków, Olga, et al.
Publicado: (2012)

Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer
por: Jiang, Liyan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9b68aom3qe7kdq616n2huspbvc