Loss of HAT1 expression confers BRAFV600E inhibitor resistance to melanoma cells by activating MAPK signaling via IGF1R

BRAF inhibitors (BRAFi) have been approved for the clinical treatment of BRAF-mutant metastatic melanoma. Although initial responses to BRAFi are generally favorable, acquired BRAFi resistance emerges rapidly, resulting in treatment failure. Only some of the underlying mechanisms responsible for BRA...

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Detalles Bibliográficos
Autores principales: Bugide, Suresh, Parajuli, Keshab Raj, Chava, Suresh, Pattanayak, Rudradip, Manna, Deborah L. Della, Shrestha, Deepmala, Yang, Eddy S., Cai, Guoping, Johnson, Douglas B., Gupta, Romi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200761/
https://www.ncbi.nlm.nih.gov/pubmed/32371878
http://dx.doi.org/10.1038/s41389-020-0228-x

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