Cargando…

In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o

Parasite-mediated diseases like malaria and schistosomiasis are growing health problems worldwide and novel drug candidates are urgently needed. In this study, the in-vitro safety profile of steroid compound 1o (sc1o), effective against the parasites Plasmodium falciparum and Schistosoma mansoni wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blum, Leonard, Gul, Sheraz, Ulshöfer, Thomas, Henke, Marina, Krieg, Reimar, Berneburg, Isabell, Thomas, Dominique, Trautmann, Sandra, Kurz, Jennifer, Geyer, Joachim, Geisslinger, Gerd, Becker, Katja, Parnham, Michael J., Schiffmann, Susanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200784/ https://www.ncbi.nlm.nih.gov/pubmed/32371995 http://dx.doi.org/10.1038/s41598-020-64382-w

Ejemplares similares

The immunomodulatory potential of the arylmethylaminosteroid sc1o
por: Blum, Leonard, et al.
Publicado: (2020)

Natural antiviral compound silvestrol modulates human monocyte‐derived macrophages and dendritic cells
por: Blum, Leonard, et al.
Publicado: (2020)

Unraveling the Pharmacological Potential of Lichen Extracts in the Context of Cancer and Inflammation With a Broad Screening Approach
por: Ingelfinger, Rebecca, et al.
Publicado: (2020)

Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes
por: Kurz, Jennifer, et al.
Publicado: (2019)

Sodium Bituminosulfonate Used to Treat Rosacea Modulates Generation of Inflammatory Mediators by Primary Human Neutrophils
por: Schiffmann, Susanne, et al.
Publicado: (2021)

In Vitro Safety, Off-Target and Bioavailability Profile of the Antiviral Compound Silvestrol
por: Schiffmann, Susanne, et al.
Publicado: (2022)

Characterization of ACE Inhibitors and AT(1)R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model
por: Reus, Philipp, et al.
Publicado: (2021)

Comparing the Effects of Rocaglates on Energy Metabolism and Immune Modulation on Cells of the Human Immune System
por: Schiffmann, Susanne, et al.
Publicado: (2023)

Pharmacological plasticity—How do you hit a moving target?
por: Parnham, Michael J., et al.
Publicado: (2019)

The role of antidrug antibodies in ustekinumab therapy and the impact of methotrexate
por: Mojtahed Poor, Sorwe, et al.
Publicado: (2023)

4 Ds in health research—working together toward rapid precision medicine
por: Niederberger, Ellen, et al.
Publicado: (2019)

The Pharmacological Potential of Novel Melittin Variants from the Honeybee and Solitary Bees against Inflammation and Cancer
por: Erkoc, Pelin, et al.
Publicado: (2022)

High-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion
por: Shiratori, Hiromi, et al.
Publicado: (2016)

Machine-Learned Data Structures of Lipid Marker Serum Concentrations in Multiple Sclerosis Patients Differ from Those in Healthy Subjects
por: Lötsch, Jörn, et al.
Publicado: (2017)

Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy
por: Lötsch, Jörn, et al.
Publicado: (2018)

Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain
por: Berneburg, Isabell, et al.
Publicado: (2022)

The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated
por: Bazarganipour, Sarah, et al.
Publicado: (2019)

Monoclonal Antibodies in Preclinical EAE Models of Multiple Sclerosis: A Systematic Review
por: Schmitz, Katja, et al.
Publicado: (2017)

T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model
por: El-Hindi, Khadija, et al.
Publicado: (2022)

The Roles of Long-Term Hyperhomocysteinemia and Micronutrient Supplementation in the App(NL–G–F) Model of Alzheimer’s Disease
por: Nieraad, Hendrik, et al.
Publicado: (2022)

R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice
por: Schmitz, Katja, et al.
Publicado: (2014)

Sphingolipid and Endocannabinoid Profiles in Adult Attention Deficit Hyperactivity Disorder
por: Brunkhorst-Kanaan, Nathalie, et al.
Publicado: (2021)

R-Flurbiprofen Traps Prostaglandins within Cells by Inhibition of Multidrug Resistance-Associated Protein-4
por: Wobst, Ivonne, et al.
Publicado: (2016)

Effects of Alzheimer-Like Pathology on Homocysteine and Homocysteic Acid Levels—An Exploratory In Vivo Kinetic Study
por: Nieraad, Hendrik, et al.
Publicado: (2021)

Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice
por: Schmitz, Katja, et al.
Publicado: (2021)

Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics
por: Runfola, Massimiliano, et al.
Publicado: (2020)

From Cancer to Immune-Mediated Diseases and Tolerance Induction: Lessons Learned From Immune Oncology and Classical Anti-cancer Treatment
por: Klöß, Stephan, et al.
Publicado: (2020)

Increased Fat Taste Preference in Progranulin-Deficient Mice
por: Schumann, Lana, et al.
Publicado: (2021)

Parasitism and Physiological Trade-Offs in Stressed Capybaras
por: Eberhardt, Ayelen T., et al.
Publicado: (2013)

Structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase and Inhibition by Phosphine Gold(I) Complexes: A Potential Approach to Leishmaniasis Treatment
por: Berneburg, Isabell, et al.
Publicado: (2023)

Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis
por: Schmitz, K., et al.
Publicado: (2017)

Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation
por: El-Hindi, Khadija, et al.
Publicado: (2020)

Trehalose Reduces Nerve Injury Induced Nociception in Mice but Negatively Affects Alertness
por: Kraft, Vanessa, et al.
Publicado: (2021)

Mesopredatory fishes from the subtropical upwelling region off NW-Africa characterised by their parasite fauna
por: Alt, Katharina G., et al.
Publicado: (2018)

Charge passing off-axis through a cylindrical resonator with beam pipes
por: Henke, H
Publicado: (1985)

UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells
por: Schömel, Nina, et al.
Publicado: (2020)

Drug Repurposing to Target Neuroinflammation and Sensory Neuron-Dependent Pain
por: Sisignano, Marco, et al.
Publicado: (2022)

Impact of Hyperhomocysteinemia and Different Dietary Interventions on Cognitive Performance in a Knock-in Mouse Model for Alzheimer’s Disease
por: Nieraad, Hendrik, et al.
Publicado: (2020)

Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin
por: Roser, Luise A., et al.
Publicado: (2023)

Mast cell tetrahydrobiopterin contributes to itch in mice
por: Zschiebsch, Katja, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_722kd67hpfcskdf76297n8vboq