High-Throughput Generation of Bipod (Fab × scFv) Bispecific Antibodies Exploits Differential Chain Expression and Affinity Capture

Generation of bispecific antibodies (BsAbs) having two unique Fab domains requires heterodimerization of the two heavy chains and pairing of each heavy chain with its cognate light chain. An alternative bispecific scaffold (Bipod) comprising an scFv and a Fab on a heterodimeric Fc eliminates the pos...

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Detalles Bibliográficos
Autores principales: Nesspor, Thomas C., Kinealy, Kyle, Mazzanti, Nicholas, Diem, Michael D., Boye, Kevin, Hoffman, Hunter, Springer, Christine, Sprenkle, Justin, Powers, Gordon, Jiang, Haiyan, La Porte, Sherry L., Ganesan, Rajkumar, Singh, Sanjaya, Zwolak, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200789/
https://www.ncbi.nlm.nih.gov/pubmed/32372058
http://dx.doi.org/10.1038/s41598-020-64536-w

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