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Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion

OBJECTIVE: Glucagon-like peptide-1 is a nutrient-sensitive hormone secreted from enteroendocrine L cells within the small and large bowel. Although GLP-1 levels rise rapidly in response to food ingestion, the greatest density of L cells is localized to the distal small bowel and colon. Here, we asse...

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Detalles Bibliográficos
Autores principales:	Panaro, Brandon L., Yusta, Bernardo, Matthews, Dianne, Koehler, Jacqueline A., Song, Youngmi, Sandoval, Darleen A., Drucker, Daniel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200938/ https://www.ncbi.nlm.nih.gov/pubmed/32278655 http://dx.doi.org/10.1016/j.molmet.2020.100990

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