Cargando…
Investigation of a Salmonellosis Outbreak Caused by Multidrug Resistant Salmonella Typhimurium in China
The rapid emergence of multidrug resistant Salmonella is a global public-health concern as outbreaks in recent years have mostly been caused by multidrug resistant strains. Here, we evaluated an outbreak in China caused by multidrug resistant Salmonella enterica serovar Typhimurium (S. Typhimurium)...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200987/ https://www.ncbi.nlm.nih.gov/pubmed/32411120 http://dx.doi.org/10.3389/fmicb.2020.00801 |
_version_ | 1783529451135434752 |
---|---|
author | Xiang, Ying Li, Fuxiang Dong, Nian Tian, Sai Zhang, Haoran Du, Xinying Zhou, Xuan Xu, Xuebin Yang, Hongxia Xie, Jing Yang, Chaojie Liu, Hongbo Qiu, Shaofu Song, Hongbin Sun, Yansong |
author_facet | Xiang, Ying Li, Fuxiang Dong, Nian Tian, Sai Zhang, Haoran Du, Xinying Zhou, Xuan Xu, Xuebin Yang, Hongxia Xie, Jing Yang, Chaojie Liu, Hongbo Qiu, Shaofu Song, Hongbin Sun, Yansong |
author_sort | Xiang, Ying |
collection | PubMed |
description | The rapid emergence of multidrug resistant Salmonella is a global public-health concern as outbreaks in recent years have mostly been caused by multidrug resistant strains. Here, we evaluated an outbreak in China caused by multidrug resistant Salmonella enterica serovar Typhimurium (S. Typhimurium) by employing an epidemiological and laboratory investigation using conventional methods and whole genome sequencing (WGS). Eleven of the 12 people who participated in a banquet showed gastrointestinal symptoms, and 8S. Typhimurium strains were recovered. Isolated outbreak strains showed multidrug resistance (MDR), and decreased susceptibility to ciprofloxacin, a first-line drug recommended by WHO for clinical treatment of intestinal infections. Antimicrobial resistance (AMR) gene analysis indicated that the MDR phenotype of these outbreak strains may be due to the presence of a number of AMR genes, including the blaOXA-1 and blaTEM-1 β-lactamase genes, which are often plasmid-borne and easily transferred. Further virulence gene analysis indicated that these outbreak strains also carried a large number of virulence genes, including 2 types of Salmonella pathogenicity islands (SPI-1 and SPI-2) and many adhesion-related virulence genes. Cluster analysis based on pulse-field gel electrophoresis data and phylogenetic analysis based on WGS revealed that the outbreak clone was closely related to and thus probably derived from local strains. This outbreak caused by multidrug resistant S. Typhimurium highlights the need for government improved strategies for the prevention and control of Salmonella infections. |
format | Online Article Text |
id | pubmed-7200987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72009872020-05-14 Investigation of a Salmonellosis Outbreak Caused by Multidrug Resistant Salmonella Typhimurium in China Xiang, Ying Li, Fuxiang Dong, Nian Tian, Sai Zhang, Haoran Du, Xinying Zhou, Xuan Xu, Xuebin Yang, Hongxia Xie, Jing Yang, Chaojie Liu, Hongbo Qiu, Shaofu Song, Hongbin Sun, Yansong Front Microbiol Microbiology The rapid emergence of multidrug resistant Salmonella is a global public-health concern as outbreaks in recent years have mostly been caused by multidrug resistant strains. Here, we evaluated an outbreak in China caused by multidrug resistant Salmonella enterica serovar Typhimurium (S. Typhimurium) by employing an epidemiological and laboratory investigation using conventional methods and whole genome sequencing (WGS). Eleven of the 12 people who participated in a banquet showed gastrointestinal symptoms, and 8S. Typhimurium strains were recovered. Isolated outbreak strains showed multidrug resistance (MDR), and decreased susceptibility to ciprofloxacin, a first-line drug recommended by WHO for clinical treatment of intestinal infections. Antimicrobial resistance (AMR) gene analysis indicated that the MDR phenotype of these outbreak strains may be due to the presence of a number of AMR genes, including the blaOXA-1 and blaTEM-1 β-lactamase genes, which are often plasmid-borne and easily transferred. Further virulence gene analysis indicated that these outbreak strains also carried a large number of virulence genes, including 2 types of Salmonella pathogenicity islands (SPI-1 and SPI-2) and many adhesion-related virulence genes. Cluster analysis based on pulse-field gel electrophoresis data and phylogenetic analysis based on WGS revealed that the outbreak clone was closely related to and thus probably derived from local strains. This outbreak caused by multidrug resistant S. Typhimurium highlights the need for government improved strategies for the prevention and control of Salmonella infections. Frontiers Media S.A. 2020-04-29 /pmc/articles/PMC7200987/ /pubmed/32411120 http://dx.doi.org/10.3389/fmicb.2020.00801 Text en Copyright © 2020 Xiang, Li, Dong, Tian, Zhang, Du, Zhou, Xu, Yang, Xie, Yang, Liu, Qiu, Song and Sun. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Xiang, Ying Li, Fuxiang Dong, Nian Tian, Sai Zhang, Haoran Du, Xinying Zhou, Xuan Xu, Xuebin Yang, Hongxia Xie, Jing Yang, Chaojie Liu, Hongbo Qiu, Shaofu Song, Hongbin Sun, Yansong Investigation of a Salmonellosis Outbreak Caused by Multidrug Resistant Salmonella Typhimurium in China |
title | Investigation of a Salmonellosis Outbreak Caused by Multidrug Resistant Salmonella Typhimurium in China |
title_full | Investigation of a Salmonellosis Outbreak Caused by Multidrug Resistant Salmonella Typhimurium in China |
title_fullStr | Investigation of a Salmonellosis Outbreak Caused by Multidrug Resistant Salmonella Typhimurium in China |
title_full_unstemmed | Investigation of a Salmonellosis Outbreak Caused by Multidrug Resistant Salmonella Typhimurium in China |
title_short | Investigation of a Salmonellosis Outbreak Caused by Multidrug Resistant Salmonella Typhimurium in China |
title_sort | investigation of a salmonellosis outbreak caused by multidrug resistant salmonella typhimurium in china |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200987/ https://www.ncbi.nlm.nih.gov/pubmed/32411120 http://dx.doi.org/10.3389/fmicb.2020.00801 |
work_keys_str_mv | AT xiangying investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT lifuxiang investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT dongnian investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT tiansai investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT zhanghaoran investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT duxinying investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT zhouxuan investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT xuxuebin investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT yanghongxia investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT xiejing investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT yangchaojie investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT liuhongbo investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT qiushaofu investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT songhongbin investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina AT sunyansong investigationofasalmonellosisoutbreakcausedbymultidrugresistantsalmonellatyphimuriuminchina |