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Neurovascular Unit Dysfunction and Neurodegenerative Disorders
The neurovascular unit (NVU), composed of vascular cells, glial cells, and neurons, is the minimal functional unit of the brain. The NVU maintains integrity of the blood–brain barrier (BBB) and regulates supply of the cerebral blood flow (CBF), both of which are keys to maintaining normal brain func...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201055/ https://www.ncbi.nlm.nih.gov/pubmed/32410936 http://dx.doi.org/10.3389/fnins.2020.00334 |
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author | Yu, Xing Ji, Caihong Shao, Anwen |
author_facet | Yu, Xing Ji, Caihong Shao, Anwen |
author_sort | Yu, Xing |
collection | PubMed |
description | The neurovascular unit (NVU), composed of vascular cells, glial cells, and neurons, is the minimal functional unit of the brain. The NVU maintains integrity of the blood–brain barrier (BBB) and regulates supply of the cerebral blood flow (CBF), both of which are keys to maintaining normal brain function. BBB dysfunction and a decreased CBF are early pathophysiological changes in neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). In this review, we primarily focus on the NVU in AD as much research has been performed on the connection between NVU dysfunction and AD. We also discuss the role of NVU dysfunction in the pathophysiological mechanisms of PD and ALS. As most neurodegenerative diseases are difficult to treat, we discuss several potential drug targets that focus on the NVU that may inform novel vascular-targeted therapies for AD, PD, and ALS. |
format | Online Article Text |
id | pubmed-7201055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72010552020-05-14 Neurovascular Unit Dysfunction and Neurodegenerative Disorders Yu, Xing Ji, Caihong Shao, Anwen Front Neurosci Neuroscience The neurovascular unit (NVU), composed of vascular cells, glial cells, and neurons, is the minimal functional unit of the brain. The NVU maintains integrity of the blood–brain barrier (BBB) and regulates supply of the cerebral blood flow (CBF), both of which are keys to maintaining normal brain function. BBB dysfunction and a decreased CBF are early pathophysiological changes in neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). In this review, we primarily focus on the NVU in AD as much research has been performed on the connection between NVU dysfunction and AD. We also discuss the role of NVU dysfunction in the pathophysiological mechanisms of PD and ALS. As most neurodegenerative diseases are difficult to treat, we discuss several potential drug targets that focus on the NVU that may inform novel vascular-targeted therapies for AD, PD, and ALS. Frontiers Media S.A. 2020-04-29 /pmc/articles/PMC7201055/ /pubmed/32410936 http://dx.doi.org/10.3389/fnins.2020.00334 Text en Copyright © 2020 Yu, Ji and Shao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Yu, Xing Ji, Caihong Shao, Anwen Neurovascular Unit Dysfunction and Neurodegenerative Disorders |
title | Neurovascular Unit Dysfunction and Neurodegenerative Disorders |
title_full | Neurovascular Unit Dysfunction and Neurodegenerative Disorders |
title_fullStr | Neurovascular Unit Dysfunction and Neurodegenerative Disorders |
title_full_unstemmed | Neurovascular Unit Dysfunction and Neurodegenerative Disorders |
title_short | Neurovascular Unit Dysfunction and Neurodegenerative Disorders |
title_sort | neurovascular unit dysfunction and neurodegenerative disorders |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201055/ https://www.ncbi.nlm.nih.gov/pubmed/32410936 http://dx.doi.org/10.3389/fnins.2020.00334 |
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