Cargando…

Computational approach to study the synthesis of noscapine and potential of stereoisomers against nsP3 protease of CHIKV

Chikungunya fever is a major public health issue in India affecting millions of people and occurs due to Chikungunya. Chikungunya virus (CHIKV) is a single stranded RNA virus from the family of Togaviridae and genus alpha virus. It contain three structural proteins: glycosylated E1 and E2, embedded...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Prashant, Kumar, Durgesh, Vishvakarma, Vijay Kumar, Yadav, Parul, Jayaraj, Abhilash, Kumari, Kamlesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201138/ https://www.ncbi.nlm.nih.gov/pubmed/32382664 http://dx.doi.org/10.1016/j.heliyon.2019.e02795

Ejemplares similares

In-silico prediction of novel drug-target complex of nsp3 of CHIKV through molecular dynamic simulation
por: Kumar, Durgesh, et al.
Publicado: (2020)

A model to study the inhibition of nsP2B-nsP3 protease of dengue virus with imidazole, oxazole, triazole thiadiazole, and thiazolidine based scaffolds
por: Vishvakarma, Vijay Kumar, et al.
Publicado: (2019)

Evaluation of the Antiviral Potential of Halogenated Dihydrorugosaflavonoids and Molecular Modeling with nsP3 Protein of Chikungunya Virus (CHIKV)
por: Puranik, Ninad V., et al.
Publicado: (2019)

Xanthene based hybrid analogues to inhibit protease of novel corona Virus: Molecular docking and ADMET studies
por: Kumar Vishvakarma, Vijay, et al.
Publicado: (2020)

Hunting the main protease of SARS-CoV-2 by plitidepsin: Molecular docking and temperature-dependent molecular dynamics simulations
por: Vishvakarma, Vijay Kumar, et al.
Publicado: (2021)

Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation
por: Rathore, Abhay P S, et al.
Publicado: (2013)

Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity
por: Kumar, Sameer, et al.
Publicado: (2018)

Full length and protease domain activity of chikungunya virus nsP2 differ from other alphavirus nsP2 proteases in recognition of small peptide substrates
por: Saisawang, Chonticha, et al.
Publicado: (2015)

Expression and biochemical characterization of nsP2 cysteine protease of Chikungunya virus
por: Pastorino, Boris A.M., et al.
Publicado: (2008)

Identical Strength of the T Cell Responses against E2, nsP1 and Capsid CHIKV Proteins in Recovered and Chronic Patients after the Epidemics of 2005-2006 in La Reunion Island
por: Hoarau, Jean-Jacques, et al.
Publicado: (2013)

1,3-Thiazolbenzamide Derivatives as Chikungunya Virus nsP2 Protease Inhibitors
por: Ivanova, Larisa, et al.
Publicado: (2021)

Interactions between main protease of SARS-CoV-2 and testosterone or progesterone using computational approach
por: Vishvakarma, Vijay Kumar, et al.
Publicado: (2022)

Analysis of chikungunya virus proteins reveals that non-structural proteins nsP2 and nsP3 exhibit RNA interference (RNAi) suppressor activity
por: Mathur, Kalika, et al.
Publicado: (2016)

Molecular Modeling and Docking Study to Elucidate Novel Chikungunya Virus nsP2 Protease Inhibitors
por: Agarwal, T., et al.
Publicado: (2015)

Sindbis Virus nsP2 Endopeptidase
por: Strauss, Ellen G., et al.
Publicado: (2013)

Impact of CHIKV Replication on the Global Proteome of Aedes albopictus Cells
por: Kumar, Ramesh, et al.
Publicado: (2022)

Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine
por: Saisawang, Chonticha, et al.
Publicado: (2015)

Characterization of the cysteine protease domain of Semliki Forest virus replicase protein nsP2 by in vitro mutagenesis
por: Golubtsov, Andrey, et al.
Publicado: (2006)

Chemoenzymatic Synthesis of the Most Pleasant Stereoisomer of Jessemal
por: Venturi, Silvia, et al.
Publicado: (2022)

Noscapine Acts as a Protease Inhibitor of In Vitro Elastase-Induced Collagen Deposition in Equine Endometrium
por: Amaral, Ana, et al.
Publicado: (2021)

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue
por: Rausalu, Kai, et al.
Publicado: (2016)

Noscapine Prevents Rotenone-Induced Neurotoxicity: Involvement of Oxidative Stress, Neuroinflammation and Autophagy Pathways
por: Jayaraj, Richard L., et al.
Publicado: (2021)

A new antiproliferative noscapine analogue: chemical synthesis and biological evaluation
por: Ghaly, Peter E., et al.
Publicado: (2016)

Challenges in Surveillance for Chikungunya Virus (CHIKV) Infection
por: Lucero-Obusan, Cynthia A., et al.
Publicado: (2015)

Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus
por: Saha, Amrita, et al.
Publicado: (2018)

Deciphering the Binding Mechanism of Noscapine with Lysozyme: Biophysical and Chemoinformatic Approaches
por: Sood, Damini, et al.
Publicado: (2019)

Interactions of Alphavirus nsP3 Protein with Host Proteins
por: Lark, Tyler, et al.
Publicado: (2018)

Hydroxychloroquine Inhibits Zika Virus NS2B-NS3 Protease
por: Kumar, Ankur, et al.
Publicado: (2018)

L-amino-acids as immunity booster against COVID-19: DFT, molecular docking and MD simulations
por: Singh, Prashant, et al.
Publicado: (2022)

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast
por: Li, Yanran, et al.
Publicado: (2016)

In Silico Evaluation of Binding of 2-Deoxy-D-Glucose with Mpro of nCoV to Combat COVID-19
por: Raman, Anirudh Pratap Singh, et al.
Publicado: (2022)

Targeting the nsp2 Cysteine Protease of Chikungunya Virus Using FDA Approved Library and Selected Cysteine Protease Inhibitors
por: Kumar, Prateek, et al.
Publicado: (2019)

Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents
por: Tomar, Vartika, et al.
Publicado: (2019)

Rational Design, Synthesis, and Biological Evaluation of Third Generation α-Noscapine Analogues as Potent Tubulin Binding Anti-Cancer Agents
por: Manchukonda, Naresh Kumar, et al.
Publicado: (2013)

Directed Biosynthesis of Mitragynine Stereoisomers
por: Schotte, Carsten, et al.
Publicado: (2023)

Discovery of Mosquito Saliva MicroRNAs during CHIKV Infection
por: Maharaj, Payal D., et al.
Publicado: (2015)

Peptide aptamer-based time-resolved fluoroimmunoassay for CHIKV diagnosis
por: Liu, Tonggong, et al.
Publicado: (2023)

Strategic considerations on developing a CHIKV vaccine and ensuring equitable access for countries in need
por: Cherian, Neil, et al.
Publicado: (2023)

Comparative evaluation of anti-angiogenic effects of noscapine derivatives
por: Meher, Rajesh K., et al.
Publicado: (2018)

Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers
por: Mohammadi Ziarani, Ghodsi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_q8blupe16gva656hse7bs9teuu