Cargando…

Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci

BACKGROUND: Defining regulatory mechanisms through which noncoding risk variants influence the cell-mediated pathogenesis of immune-mediated disease (IMD) has emerged as a priority in the post–genome-wide association study era. OBJECTIVES: With a focus on rheumatoid arthritis, we sought new insight...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clark, Alexander D., Nair, Nisha, Anderson, Amy E., Thalayasingam, Nishanthi, Naamane, Najib, Skelton, Andrew J., Diboll, Julie, Barton, Anne, Eyre, Stephen, Isaacs, John D., Pratt, Arthur G., Reynard, Louise N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mosby 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201180/ https://www.ncbi.nlm.nih.gov/pubmed/31945409 http://dx.doi.org/10.1016/j.jaci.2019.12.910

Ejemplares similares

CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification
por: Thalayasingam, Nishanthi, et al.
Publicado: (2018)

Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming
por: Cooles, Faye A H, et al.
Publicado: (2022)

A Bayesian network approach incorporating imputation of missing data enables exploratory analysis of complex causal biological relationships
por: Howey, Richard, et al.
Publicado: (2021)

Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23
por: McGovern, Amanda, et al.
Publicado: (2016)

IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function
por: Ridgley, Laura A., et al.
Publicado: (2019)

Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis
por: Anderson, Amy E, et al.
Publicado: (2019)

Immune reconstitution 20 years after treatment with alemtuzumab in a rheumatoid arthritis cohort: implications for lymphocyte depleting therapies
por: Cooles, Faye A. H., et al.
Publicado: (2016)

New developments in Sjogren’s syndrome
por: Thalayasingam, Nishanthi, et al.
Publicado: (2021)

Pre-treatment calprotectin (MRP8/14) provides no added value to testing CRP alone in terms of predicting response to TNF inhibitors in rheumatoid arthritis in a post hoc analysis
por: Smith, Samantha Louise, et al.
Publicado: (2023)

Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes Through the Identification and Characterization of Novel Methylation Quantitative Trait Loci
por: Rice, Sarah J., et al.
Publicado: (2019)

In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells
por: Naamane, Najib, et al.
Publicado: (2007)

Generation of dexamethasone and vitamin D3-treated human monocyte-derived dendritic cells with tolerogenic properties
por: Sayers, Bethan, et al.
Publicado: (2007)

Tolerogenic dendritic cells differentially modulate naïve and memory CD4(+ )T cells
por: Anderson, Amy E, et al.
Publicado: (2007)

Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874
por: Shepherd, Colin, et al.
Publicado: (2015)

Fusion transcript loci share many genomic features with non-fusion loci
por: Lai, John, et al.
Publicado: (2015)

Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study
por: Baker, Kenneth F., et al.
Publicado: (2019)

Erratum to “Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study” [J. Autoimmun. 105 (December 2019) 102298]
por: Baker, Kenneth F., et al.
Publicado: (2022)

Erratum to: Fusion transcript loci share many genomic features with non-fusion loci
por: Lai, John, et al.
Publicado: (2016)

Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis
por: Hinks, Anne, et al.
Publicado: (2010)

Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis
por: Plant, Darren, et al.
Publicado: (2016)

Shared genetic loci between depression and cardiometabolic traits
por: Torgersen, Kristin, et al.
Publicado: (2022)

Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis
por: Hinks, Anne, et al.
Publicado: (2010)

Identification of shared risk loci and pathways for bipolar disorder and schizophrenia
por: Forstner, Andreas J., et al.
Publicado: (2017)

Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases
por: Burren, Oliver S., et al.
Publicado: (2020)

Enrichment of Vitamin D response elements in RA associated loci supports a role for vitamin D in the pathogenesis of RA
por: Yarwood, Annie, et al.
Publicado: (2013)

The 752delG26 mutation in the RFXANK gene associated with major histocompatibility complex class II deficiency: evidence for a founder effect in the Moroccan population
por: Naamane, H, et al.
Publicado: (2011)

A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease
por: Pratt, Arthur G, et al.
Publicado: (2012)

Private specificities of H-2K and H-2D loci as possible selective targets for effector lymphocytes in cell-mediated immunity
Publicado: (1975)

Lymphocytes and Trogocytosis-Mediated Signaling
por: Reed, Jim, et al.
Publicado: (2021)

The predictive value of serum S100A9 and response to etanercept is not confirmed in a large UK rheumatoid arthritis cohort
por: Smith, Samantha Louise, et al.
Publicado: (2017)

14.5 Rheumatoid Arthritis susceptibility loci; STAT4, TRAF1/C5 and 6q23 region, are also associated with Juvenile Idiopathic Arthritis
por: Hinks, A, et al.
Publicado: (2008)

Susceptibility Loci Associated with Specific and Shared Subtypes of Lymphoid Malignancies
por: Vijai, Joseph, et al.
Publicado: (2013)

Common Expression Quantitative Trait Loci Shared by Histone Genes
por: Kim, Hanseol, et al.
Publicado: (2017)

Exploring Lead loci shared between schizophrenia and Cardiometabolic traits
por: He, Qian, et al.
Publicado: (2022)

B lymphocytes as emerging mediators of insulin resistance
por: Winer, D A, et al.
Publicado: (2012)

Computational analysis of five neurodegenerative diseases reveals shared and specific genetic loci
por: Maselli, Francesca, et al.
Publicado: (2023)

Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap
por: Hinks, Anne, et al.
Publicado: (2012)

Current concepts in the pathogenesis of early rheumatoid arthritis
por: Pratt, Arthur G., et al.
Publicado: (2009)

CrEdit: CRISPR mediated multi-loci gene integration in Saccharomyces cerevisiae
por: Ronda, Carlotta, et al.
Publicado: (2015)

Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis
por: Cooles, Faye A. H., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_sfasjl9ktctjp5osjaiuc6osk8