Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?

The ongoing SARS-CoV2 outbreak has developed into a global pandemic. Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a vaccine nor any other medication for an effective treatment are currently available. Endo-lysosomal two-pore cation channels have now emerge...

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Detalles Bibliográficos
Autores principales: Grimm, Christian, Tang, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201244/
https://www.ncbi.nlm.nih.gov/pubmed/32402856
http://dx.doi.org/10.1016/j.ceca.2020.102212
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author Grimm, Christian
Tang, Rachel
author_facet Grimm, Christian
Tang, Rachel
author_sort Grimm, Christian
collection PubMed
description The ongoing SARS-CoV2 outbreak has developed into a global pandemic. Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a vaccine nor any other medication for an effective treatment are currently available. Endo-lysosomal two-pore cation channels have now emerged as potential novel targets for SARS-CoV treatment.
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spelling pubmed-72012442020-05-06 Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2? Grimm, Christian Tang, Rachel Cell Calcium Article The ongoing SARS-CoV2 outbreak has developed into a global pandemic. Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a vaccine nor any other medication for an effective treatment are currently available. Endo-lysosomal two-pore cation channels have now emerged as potential novel targets for SARS-CoV treatment. Elsevier Ltd. 2020-06 2020-05-06 /pmc/articles/PMC7201244/ /pubmed/32402856 http://dx.doi.org/10.1016/j.ceca.2020.102212 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Grimm, Christian
Tang, Rachel
Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?
title Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?
title_full Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?
title_fullStr Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?
title_full_unstemmed Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?
title_short Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?
title_sort could an endo-lysosomal ion channel be the achilles heel of sars-cov2?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201244/
https://www.ncbi.nlm.nih.gov/pubmed/32402856
http://dx.doi.org/10.1016/j.ceca.2020.102212
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